ADP-Ribosylation of Neurofilaments by a Cytoplasmic ADP-Ribose Transferase Associated with Free mRNP

ADP-Ribosylation of Neurofilaments by a Cytoplasmic ADP-Ribose Transferase Associated with Free mRNP

ADP-ribosylation of neurofilaments by an ADP-ribose transferase isolated from cytoplasmic ribonucleoprotein particles is demonstrated. The 150 kDa neurofilament subunit appears to be the main ADP-ribose acceptor with the transfer of ADP-ribose dimers or monomers. A binding of about 1 mole ADP-ribose...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Biochemical and biophysical research communications 1993-07, Vol.194 (2), p.916-922
Hauptverfasser: Jesser, M., Hog, F., Chypre, C., Leterrier, J.F., Mandel, P.
Format: Artikel
Sprache:eng
Schlagworte:
Adenosine Diphosphate Ribose - metabolism
Analytical, structural and metabolic biochemistry
Animals
Biological and medical sciences
Blotting, Western
Cations, Divalent - pharmacology
Cattle
Cytosol - enzymology
Electrophoresis, Polyacrylamide Gel
Enzymes and enzyme inhibitors
Fundamental and applied biological sciences. Psychology
Intermediate Filaments - metabolism
Kinetics
Mice
Mice, Inbred BALB C
NAD - metabolism
Poly(ADP-ribose) Polymerases - metabolism
Protein Processing, Post-Translational
Rats
Ribonucleoproteins - metabolism
Transferases
Tumor Cells, Cultured
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:ADP-ribosylation of neurofilaments by an ADP-ribose transferase isolated from cytoplasmic ribonucleoprotein particles is demonstrated. The 150 kDa neurofilament subunit appears to be the main ADP-ribose acceptor with the transfer of ADP-ribose dimers or monomers. A binding of about 1 mole ADP-ribose per 8 moles of neurofilament subunits has been recorded. An interaction between neurofilaments′ ADP-ribosylation and their phosphorylation state is demonstrated.
ISSN:0006-291X
1090-2104
DOI:10.1006/bbrc.1993.1908