Association of vitamin D receptor Taq I polymorphism and susceptibility to oral squamous cell carcinoma

It has been hypothesised that vitamin D receptor (VDR) gene polymorphisms may influence both the risk of cancer occurrence and prognosis. The distribution of VDR Taq I polymorphism in 64 patients with OSCC was determined by polymerase chain reaction based restriction fragment length polymorphism (RF...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	In vivo (Athens) 2010-09, Vol.24 (5), p.755-759
Hauptverfasser:	Bektas-Kayhan, Kivanç, Unür, Meral, Yaylim-Eraltan, Ilhan, Ergen, H Arzu, Toptas, Bahar, Hafiz, Günter, Karadeniz, Ahmet, Isbir, Turgay
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Carcinoma, Squamous Cell - epidemiology Carcinoma, Squamous Cell - genetics Case-Control Studies Female Genetic Predisposition to Disease - epidemiology Genotype Humans Male Middle Aged Mouth Neoplasms - epidemiology Mouth Neoplasms - genetics Polymorphism, Restriction Fragment Length Receptors, Calcitriol - genetics Risk Factors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	It has been hypothesised that vitamin D receptor (VDR) gene polymorphisms may influence both the risk of cancer occurrence and prognosis. The distribution of VDR Taq I polymorphism in 64 patients with OSCC was determined by polymerase chain reaction based restriction fragment length polymorphism (RFLP) and compared with that of 87 healthy controls. There was a significant difference in the distribution of VDR Taq I genotypes between OSCC patients and healthy controls. Patients with the VDR Tt genotype were found to be at significantly higher risk for OSCC than those with other genotypes (p=0.036). In particular, female OSCC patients were at higher risk (p
ISSN:	1791-7549