Removal of Extracellular Ca Stimulates Histamine Release from Rat Mast Cells by Mobilizing a Labile Cellular Source of Ca

Rat mast cells were stimulated by simultaneous removal of external Ca and Na, and their secretory mechanism was investigated. A brief EGTA-treatment of the cells markedly diminished this response with little affection the response to compound 48/80, suggesting that mobilization of Ca from labile poo...

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Veröffentlicht in:	Japanese journal of physiology 1984, Vol.34(5), pp.919-922
1. Verfasser:	SORIMACHI, Masaru
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences calcium Calcium - physiology Cell Membrane - metabolism Egtazic Acid - pharmacology Fundamental and applied biological sciences. Psychology Fundamental immunology histamine Histamine Release Immediate hypersensitivity. Allergy. Anaphylaxis, etc Immunobiology Male mast cell Mast Cells - drug effects Mast Cells - metabolism p-Methoxy-N-methylphenethylamine - pharmacology Rats Rats, Inbred Strains Reaction mechanisms, antibodies, chemical mediators Sodium - physiology
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Zusammenfassung:	Rat mast cells were stimulated by simultaneous removal of external Ca and Na, and their secretory mechanism was investigated. A brief EGTA-treatment of the cells markedly diminished this response with little affection the response to compound 48/80, suggesting that mobilization of Ca from labile pools in the membrane is involved in this response.
ISSN:	0021-521X 1881-1396
DOI:	10.2170/jjphysiol.34.919