Quantitative interpretation of magnetization transfer

Magnetization transfer contrast (MTC) experiments using off‐resonance irradiation have been performed with an agar gel model by systematically varying offset frequency, amplitude of the RF irradiation and gel concentration. The experimental results are shown to be quantitatively modelled by a two‐pool system consisting of a liquid pool with a Lorentzian line shape and a small semisolid pool with a Gaussian lineshape. The fitted model yields physically realistic fundamental parameters with a T2 of the semisolid pool of 13 μs. Further analysis shows that the off‐resonance irradiation MTC experiment has significant limitations in its ability to saturate the semisolid pool without directly affecting the liquid component.