Endogenous factor activating Na,K-ATPase induced by blockade of adrenoceptors
It was established that the regulatory factor released from the effector cells under the blockade of postsynaptic α- and β-adrenoceptors by phentolamine and propranolol (0.5–1.0 μM) and activating noradrenergic uptake and synthesis [1, 2] increased the activity of Na,K-ATPase of isolated rat organs...
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| Veröffentlicht in: | Biochemical pharmacology 1993-07, Vol.46 (1), p.125-130 |
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| container_title | Biochemical pharmacology |
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| creator | Manukhin, Boris N. Erokhov, Pavel A. Volina, Ekaterina V. |
| description | It was established that the regulatory factor released from the effector cells under the blockade of postsynaptic α- and β-adrenoceptors by phentolamine and propranolol (0.5–1.0 μM) and activating noradrenergic uptake and synthesis [1, 2] increased the activity of Na,K-ATPase of isolated rat organs and partially purified Na, K-ATPase isolated from the rat brain. The regulatory factor is a protein with molecular mass 25–100 kDa, adsorbed on phenylsepharose CL-4B and eluated with 30 mM KC1. It consists of two active components with pI 5.1 and 5.9 which in admixture (1:1) activate Na,K-ATPase by 60%. |
| doi_str_mv | 10.1016/0006-2952(93)90356-2 |
| format | Article |
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The regulatory factor is a protein with molecular mass 25–100 kDa, adsorbed on phenylsepharose CL-4B and eluated with 30 mM KC1. 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| ispartof | Biochemical pharmacology, 1993-07, Vol.46 (1), p.125-130 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adrenergic alpha-Antagonists - pharmacology Animals Brain - enzymology Enzyme Activation - drug effects Isoelectric Focusing Male Membrane Fluidity - drug effects Molecular Weight Potentiometry Rats Rats, Wistar Sodium-Potassium-Exchanging ATPase - isolation & purification Sodium-Potassium-Exchanging ATPase - metabolism Tissue Extracts - chemistry Tissue Extracts - isolation & purification Tissue Extracts - pharmacology |
| title | Endogenous factor activating Na,K-ATPase induced by blockade of adrenoceptors |
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