β-Adrenoceptor blockade spares chemoreceptor responsiveness to hypoxia

The effect of β-adrenoceptor blockade on the carotid body chemoreceptor response to hypoxia was assessed in anesthetized and paralyzed cats. Propranolol, atenolol and ICI 118,551 each abolished the enhancement of chemoreceptor activity produced by i.v. infusion of exogenous isoproterenol; however th...

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Veröffentlicht in:	Brain research 1984-12, Vol.324 (2), p.349-353
Hauptverfasser:	Gonsalves, Susan F., Smith, Edward J., Nolan, William F., Dutton, Robert E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atenolol - pharmacology Biological and medical sciences Cardiorespiratory control. Arterial mecano- and chemoreceptor Carotid Body - drug effects Carotid Body - physiopathology carotid chemoreceptors Cats Female Fundamental and applied biological sciences. Psychology Hypoxia - physiopathology hypoxic sensitivity isoproterenol Male neural discharge Propanolamines - pharmacology Propranolol - pharmacology Receptors, Adrenergic, beta - physiology Vertebrates: respiratory system β-adrenoreceptor blockade
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Zusammenfassung:	The effect of β-adrenoceptor blockade on the carotid body chemoreceptor response to hypoxia was assessed in anesthetized and paralyzed cats. Propranolol, atenolol and ICI 118,551 each abolished the enhancement of chemoreceptor activity produced by i.v. infusion of exogenous isoproterenol; however the blocking durgs did not significantly diminish the increase in chemoreceptor neural discharge induced by hypoxia. These results do not support the hypothesis that β-adrenergic receptors play an essential role in the chemoreceptor response to oxygen deprivation.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/0006-8993(84)90047-7