Metabolism of Furazolidone in Eels
The metabolism of an antibacterial nitrofuran, furazolidone (N-(5-nitro-2-furfurylidene)-3-amino-2-oxazolidone), was investigated in eels. When eels were bathed in a solution of the nitrofuran, ethyl acetate-extractable metabolites and polar, water-soluble metabolite (s) were formed from the nitrofu...
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| Veröffentlicht in: | Chemical & pharmaceutical bulletin 1984/10/25, Vol.32(10), pp.4193-4196 |
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| container_issue | 10 |
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| container_title | Chemical & pharmaceutical bulletin |
| container_volume | 32 |
| creator | NAKABEPPU, HITOSHI TATSUMI, KIYOSHI |
| description | The metabolism of an antibacterial nitrofuran, furazolidone (N-(5-nitro-2-furfurylidene)-3-amino-2-oxazolidone), was investigated in eels. When eels were bathed in a solution of the nitrofuran, ethyl acetate-extractable metabolites and polar, water-soluble metabolite (s) were formed from the nitrofuran. One of the former metabolites was isolated from the bathing solution and unequivocally identified as 3-(4-cyano-2-oxobutylideneamino)-2-oxazolidone by comparison with an authentic sample. This metabolite was also formed from the nitrofuran by an eel liver homogenate-catalyzed reaction. |
| doi_str_mv | 10.1248/cpb.32.4193 |
| format | Article |
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When eels were bathed in a solution of the nitrofuran, ethyl acetate-extractable metabolites and polar, water-soluble metabolite (s) were formed from the nitrofuran. One of the former metabolites was isolated from the bathing solution and unequivocally identified as 3-(4-cyano-2-oxobutylideneamino)-2-oxazolidone by comparison with an authentic sample. This metabolite was also formed from the nitrofuran by an eel liver homogenate-catalyzed reaction.</description><identifier>ISSN: 0009-2363</identifier><identifier>EISSN: 1347-5223</identifier><identifier>DOI: 10.1248/cpb.32.4193</identifier><identifier>PMID: 6529814</identifier><identifier>CODEN: CPBTAL</identifier><language>eng</language><publisher>Tokyo: The Pharmaceutical Society of Japan</publisher><subject>3-(4-cyano-2-oxobutylideneamino)-2-oxazolidone ; Anguilla ; Animals ; Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Biological and medical sciences ; Biotransformation ; Chromatography, Thin Layer - methods ; Eels - metabolism ; Freshwater ; Furazolidone - metabolism ; In Vitro Techniques ; Liver - metabolism ; Medical sciences ; Pharmacology. 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Pharm. Bull.</addtitle><description>The metabolism of an antibacterial nitrofuran, furazolidone (N-(5-nitro-2-furfurylidene)-3-amino-2-oxazolidone), was investigated in eels. When eels were bathed in a solution of the nitrofuran, ethyl acetate-extractable metabolites and polar, water-soluble metabolite (s) were formed from the nitrofuran. One of the former metabolites was isolated from the bathing solution and unequivocally identified as 3-(4-cyano-2-oxobutylideneamino)-2-oxazolidone by comparison with an authentic sample. This metabolite was also formed from the nitrofuran by an eel liver homogenate-catalyzed reaction.</description><subject>3-(4-cyano-2-oxobutylideneamino)-2-oxazolidone</subject><subject>Anguilla</subject><subject>Animals</subject><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Biological and medical sciences</subject><subject>Biotransformation</subject><subject>Chromatography, Thin Layer - methods</subject><subject>Eels - metabolism</subject><subject>Freshwater</subject><subject>Furazolidone - metabolism</subject><subject>In Vitro Techniques</subject><subject>Liver - metabolism</subject><subject>Medical sciences</subject><subject>Pharmacology. 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Antiinfectious agents. Antiparasitic agents</topic><topic>Biological and medical sciences</topic><topic>Biotransformation</topic><topic>Chromatography, Thin Layer - methods</topic><topic>Eels - metabolism</topic><topic>Freshwater</topic><topic>Furazolidone - metabolism</topic><topic>In Vitro Techniques</topic><topic>Liver - metabolism</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>NAKABEPPU, HITOSHI</creatorcontrib><creatorcontrib>TATSUMI, KIYOSHI</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>NAKABEPPU, HITOSHI</au><au>TATSUMI, KIYOSHI</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabolism of Furazolidone in Eels</atitle><jtitle>Chemical & pharmaceutical bulletin</jtitle><addtitle>Chem. Pharm. Bull.</addtitle><date>1984-01-01</date><risdate>1984</risdate><volume>32</volume><issue>10</issue><spage>4193</spage><epage>4196</epage><pages>4193-4196</pages><issn>0009-2363</issn><eissn>1347-5223</eissn><coden>CPBTAL</coden><abstract>The metabolism of an antibacterial nitrofuran, furazolidone (N-(5-nitro-2-furfurylidene)-3-amino-2-oxazolidone), was investigated in eels. When eels were bathed in a solution of the nitrofuran, ethyl acetate-extractable metabolites and polar, water-soluble metabolite (s) were formed from the nitrofuran. One of the former metabolites was isolated from the bathing solution and unequivocally identified as 3-(4-cyano-2-oxobutylideneamino)-2-oxazolidone by comparison with an authentic sample. 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| identifier | ISSN: 0009-2363 |
| ispartof | Chemical and Pharmaceutical Bulletin, 1984/10/25, Vol.32(10), pp.4193-4196 |
| issn | 0009-2363 1347-5223 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75902944 |
| source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | 3-(4-cyano-2-oxobutylideneamino)-2-oxazolidone Anguilla Animals Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Biotransformation Chromatography, Thin Layer - methods Eels - metabolism Freshwater Furazolidone - metabolism In Vitro Techniques Liver - metabolism Medical sciences Pharmacology. Drug treatments |
| title | Metabolism of Furazolidone in Eels |
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