Metabolism of Furazolidone in Eels

The metabolism of an antibacterial nitrofuran, furazolidone (N-(5-nitro-2-furfurylidene)-3-amino-2-oxazolidone), was investigated in eels. When eels were bathed in a solution of the nitrofuran, ethyl acetate-extractable metabolites and polar, water-soluble metabolite (s) were formed from the nitrofu...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1984/10/25, Vol.32(10), pp.4193-4196
Hauptverfasser:	NAKABEPPU, HITOSHI, TATSUMI, KIYOSHI
Format:	Artikel
Sprache:	eng
Schlagworte:	3-(4-cyano-2-oxobutylideneamino)-2-oxazolidone Anguilla Animals Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Biotransformation Chromatography, Thin Layer - methods Eels - metabolism Freshwater Furazolidone - metabolism In Vitro Techniques Liver - metabolism Medical sciences Pharmacology. Drug treatments
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Beschreibung
Zusammenfassung:	The metabolism of an antibacterial nitrofuran, furazolidone (N-(5-nitro-2-furfurylidene)-3-amino-2-oxazolidone), was investigated in eels. When eels were bathed in a solution of the nitrofuran, ethyl acetate-extractable metabolites and polar, water-soluble metabolite (s) were formed from the nitrofuran. One of the former metabolites was isolated from the bathing solution and unequivocally identified as 3-(4-cyano-2-oxobutylideneamino)-2-oxazolidone by comparison with an authentic sample. This metabolite was also formed from the nitrofuran by an eel liver homogenate-catalyzed reaction.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.32.4193