Adsorption of Amino-acetamide Derivatives from 1-Octanol Solution by Silica Gel

Adsorption of Amino-acetamide Derivatives from 1-Octanol Solution by Silica Gel

Adsorption of amino-acetamide derivatives by silica gel from 1-octanol solution, the 1-octanol/water partition coefficient and the capacity factor were investigated. The physico-chemical parameters obtained were well correlated with each other. On the other hand, there was no correlation between the...

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Veröffentlicht in:Chemical & pharmaceutical bulletin 1984/10/25, Vol.32(10), pp.4084-4088
Hauptverfasser: SUNADA, HISAKAZU, FURUKAWA, KEIKO, ISHINO, RYUZOU, OTSUKA, AKINOBU, SUGIURA, MICHIHARU, HAMADA, YOSHIKI
Format: Artikel
Sprache:eng
Schlagworte:
1-Octanol
Adsorption
Chemical Phenomena
Chemistry
Chemistry, Physical
Exact sciences and technology
General and physical chemistry
Octanols - analysis
QSAR
Silica Gel
Silicon Dioxide
Solid-liquid interface
Solutions
Surface physical chemistry
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Zusammenfassung:Adsorption of amino-acetamide derivatives by silica gel from 1-octanol solution, the 1-octanol/water partition coefficient and the capacity factor were investigated. The physico-chemical parameters obtained were well correlated with each other. On the other hand, there was no correlation between the Hammett constant and adsorption parameters. The results indicate that adsorbability measurement may provide useful information for quantitative structure-activity relationship (QSAR) studies.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.32.4084