High-Performance Liquid Chromatographic Analysis of Cyclosporine A in Human Skin

High-Performance Liquid Chromatographic Analysis of Cyclosporine A in Human Skin

A three‐dimensional high‐performance liquid chromatography (HPLC) method is described for the determination of cyclosporine A in human skin. The method allows to determine at least 3 ng cyclosporine A in 10 mg skin (total sample amount needed) and is suitable for cyclosporine A level monitoring in t...

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Veröffentlicht in:Archiv der Pharmazie (Weinheim) 1993, Vol.326 (6), p.365-368
Hauptverfasser: Husek, Aleš, Eibler, Ernst, Wiegrebe, Wolfgag
Format: Artikel
Sprache:eng
Schlagworte:
Analysis
Biological and medical sciences
Chromatography, High Pressure Liquid
Cyclosporine - analysis
General pharmacology
Humans
Medical sciences
Pharmacology. Drug treatments
Skin - chemistry
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Zusammenfassung:A three‐dimensional high‐performance liquid chromatography (HPLC) method is described for the determination of cyclosporine A in human skin. The method allows to determine at least 3 ng cyclosporine A in 10 mg skin (total sample amount needed) and is suitable for cyclosporine A level monitoring in the skin of psoriatic patients. HPLC‐Bestimmung von Cyclosporin A in menschlicher Haut Eine dreidimensionale HPLC‐Methode zur Bestimmung von ≤ 3 mg Cyclosporin A in 10 mg menschlicher Haut wird beschrieben. Dieses Verfahren eignet sich zur Cyclosporin A Bestimmung in der Haut von Psoriatikern.
ISSN:0365-6233
1521-4184
DOI:10.1002/ardp.19933260610