Amino Acids and Peptides. IV. Synthesis and Analgesic Effects of Tyr-Containing Dipeptide Phenethylamides

Amino Acids and Peptides. IV. Synthesis and Analgesic Effects of Tyr-Containing Dipeptide Phenethylamides

Several tyrosyl-5-aminovaleramide analogs were synthesized and their analgesic effects were examined. N-(Tyrosyl-5-aminovaleryl)-N-methylphenethylamine showed analgesic action in mice on peripheral administration.

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Bibliographische Detailangaben
Veröffentlicht in:Chemical & pharmaceutical bulletin 1984/10/25, Vol.32(10), pp.4157-4160
Hauptverfasser: MAEDA, MITSUKO, OKUSADA, SATOSHI, KAWASAKI, KOICHI
Format: Artikel
Sprache:eng
Schlagworte:
analgesia
Analgesics - chemical synthesis
Animals
Chemical Phenomena
Chemistry
Dipeptides - chemical synthesis
Exact sciences and technology
Mice
Organic chemistry
peptide synthesis
Peptides
Phenethylamines - chemical synthesis
Preparations and properties
Tyrosine
tyrosyl-5-aminovaleramide
tyrosylaminovaleramide
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Beschreibung
Zusammenfassung:Several tyrosyl-5-aminovaleramide analogs were synthesized and their analgesic effects were examined. N-(Tyrosyl-5-aminovaleryl)-N-methylphenethylamine showed analgesic action in mice on peripheral administration.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.32.4157