Synthesis and Gastric Antisecretory Activity of N-Cyano-N'-(phenyl-pyridinylmethyl) guanidine Derivatives

N-Alkyl-N'-cyano-N"-(substituted phenyl-pyridinylmethyl) guanidine derivatives were synthesized and tested for inhibitory activity against gastric secretion in rats. Several of the compounds synthesized showed an inhibiting activity as potent as that of cimetidine against basal gastric sec...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1984/12/25, Vol.32(12), pp.4893-4906
Hauptverfasser:	SHIMADA, KATSUTOSHI, FUJISAKI, HIDEAKI, OKETANI, KIYOSHI, MURAKAMI, MANABU, SHOJI, TADAO, WAKABAYASHI, TSUNEO, UEDA, KOICHIRO, EMA, KIICHI, HASHIMOTO, KAZUNORI, TANAKA, SATORU
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chemical Phenomena Chemistry Exact sciences and technology Gastric Mucosa - metabolism Guanidines - chemical synthesis Guanidines - pharmacology Heterocyclic compounds Heterocyclic compounds with only one n hetero atom and condensed derivatives Histamine - pharmacology histamine H2 antagonist Male Nitriles - chemical synthesis Nitriles - pharmacology Organic chemistry Preparations and properties Rats Rats, Inbred Strains Structure-Activity Relationship
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Zusammenfassung:	N-Alkyl-N'-cyano-N"-(substituted phenyl-pyridinylmethyl) guanidine derivatives were synthesized and tested for inhibitory activity against gastric secretion in rats. Several of the compounds synthesized showed an inhibiting activity as potent as that of cimetidine against basal gastric secretion but showed less potent activity than cimetidine against histamine-stimulated gastric secretion. Some structure-activity relationships are discussed.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.32.4893