VERUCOPEPTIN, A NEW ANTITUMOR ANTIBIOTIC ACTIVE AGAINST B16 MELANOMA: I. TAXONOMY, PRODUCTION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND BIOLOGICAL ACTIVITY

A new antitumor antibiotic verucopeptin was isolated from the culture broth of Actinomadura verrucosospora Q886-2. It showed potent cytotoxicity and specific in vivo activity against B16 melanoma. Maximum T/C value (162%) was obtained by Q1D×1 treatment schedule.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of antibiotics 1993/06/25, Vol.46(6), pp.921-927
Hauptverfasser:	NISHIYAMA, YUJI, SUGAWARA, KOKO, TOMITA, KOJI, YAMAMOTO, HARUAKI, KAMEI, HIDEO, OKI, TOSHIKAZU
Format:	Artikel
Sprache:	eng
Schlagworte:	Actinomadura verrucosospora Actinomycetales - chemistry Animals Antibiotics, Antineoplastic - chemistry Antibiotics, Antineoplastic - isolation & purification Antibiotics, Antineoplastic - pharmacology Antineoplastic agents Biological and medical sciences Chromatography, High Pressure Liquid Depsipeptides Fermentation General aspects Humans Leukemia L1210 - drug therapy Leukemia P388 - drug therapy Male Medical sciences Melanoma, Experimental - drug therapy Mice Microbial Sensitivity Tests Peptides, Cyclic - chemistry Peptides, Cyclic - isolation & purification Peptides, Cyclic - pharmacology Pharmacology. Drug treatments
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A new antitumor antibiotic verucopeptin was isolated from the culture broth of Actinomadura verrucosospora Q886-2. It showed potent cytotoxicity and specific in vivo activity against B16 melanoma. Maximum T/C value (162%) was obtained by Q1D×1 treatment schedule.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.46.921