XANTHOFUSIN, AN ANTIFUNGAL TETRONIC ACID FROM Fusicoccum sp.: PRODUCTION, ISOLATION AND STRUCTURE

XANTHOFUSIN, AN ANTIFUNGAL TETRONIC ACID FROM Fusicoccum sp.: PRODUCTION, ISOLATION AND STRUCTURE

During ongoing screening for antifungal metabolites of potential interest for agricultural applications, an unidentified species of Fusicoccum (IMI CC No. 351573), isolated from Mediterranean plant material, was discovered as an efficient source of a novel tetronic acid, xanthofusin (E-3,4-dihydroxy...

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Veröffentlicht in:Journal of antibiotics 1993/06/25, Vol.46(6), pp.1013-1015
Hauptverfasser: BREINHOLT, JENS, DEMUTH, HELLE, LANGE, LENE, KJÆR, ANDERS, PEDERSEN, CHRISTIAN
Format: Artikel
Sprache:eng
Schlagworte:
4-Butyrolactone - analogs & derivatives
4-Butyrolactone - isolation & purification
4-Butyrolactone - pharmacology
Animals
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antifungal agents
Antifungal Agents - isolation & purification
Antifungal Agents - pharmacology
Biological and medical sciences
Fungi - chemistry
Medical sciences
Mice
Pharmacology. Drug treatments
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Zusammenfassung:During ongoing screening for antifungal metabolites of potential interest for agricultural applications, an unidentified species of Fusicoccum (IMI CC No. 351573), isolated from Mediterranean plant material, was discovered as an efficient source of a novel tetronic acid, xanthofusin (E-3,4-dihydroxy-2-methyl-6-oxo-2,4-heptadienoic acid- gamma -lactone), which exhibited interesting antifungal activities. We report on its production, isolation, chemical structure and biological activity.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.46.1013