Bromo-6-methoxy-8-aminoquinolines: Preparation and 13C-NMR Assignments

Preparation of all possible monobromo-6-methoxy-8-amino-quinolines is reported. These materials provided an opportunity to assess the effect of bromine substitution on 13C-NMR chemical shift patterns. An explanation of the isomerization of 5-bromo-6-methoxy-8-acetamidoquinoline to 7-bromo-6-methoxy-...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1984-12, Vol.73 (12), p.1854-1856
Hauptverfasser:	McChesney, James D., Sarangan, S., Hufford, Charles D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoquinolines - chemical synthesis bromine substitution Bromine substitution-13C-NMR chemical shifts Bromine substitution—13C-NMR chemical shifts, bromo-aminoquinoline isomerization bromo-aminoquinoline isomerization Bromoaminoquinolines-13C-NMR chemical shifts Bromoaminoquinolines—13C-NMR chemical shifts, isomerization, bromine substitution Chemical Phenomena Chemistry Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with only one n hetero atom and condensed derivatives isomerization Magnetic Resonance Spectroscopy Organic chemistry Preparations and properties
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Beschreibung
Zusammenfassung:	Preparation of all possible monobromo-6-methoxy-8-amino-quinolines is reported. These materials provided an opportunity to assess the effect of bromine substitution on 13C-NMR chemical shift patterns. An explanation of the isomerization of 5-bromo-6-methoxy-8-acetamidoquinoline to 7-bromo-6-methoxy-8-aminoquinoline during hydrolysis is presented.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600731256