A malignant neoplasm with features of both squamous cell carcinoma and malignant melanoma

A case of a malignant neoplasm with features suggestive of both malignant melanoma and squamous cell carcinoma is reported. The neoplastic cells were positive for both S-100 protein and keratin when stained by the indirect peroxidase-antiperoxidase method. The literature on other instances of bi- or...

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Veröffentlicht in:	The American journal of dermatopathology 1984, Vol.6 Suppl, p.213-219
Hauptverfasser:	Rosen, L B, Williams, W D, Benson, J, Rywlin, A M
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - ultrastructure Facial Neoplasms - pathology Facial Neoplasms - ultrastructure Female Humans Keratins - analysis Melanoma - pathology Melanoma - ultrastructure Neoplasms, Multiple Primary - pathology Neoplasms, Multiple Primary - ultrastructure S100 Proteins - analysis
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Beschreibung
Zusammenfassung:	A case of a malignant neoplasm with features suggestive of both malignant melanoma and squamous cell carcinoma is reported. The neoplastic cells were positive for both S-100 protein and keratin when stained by the indirect peroxidase-antiperoxidase method. The literature on other instances of bi- or multidirectional differentiation of neoplastic cells is reviewed. The significance of these findings for terminology of neoplasms is discussed.
ISSN:	0193-1091