INFLUENCE OF RENAL FUNCTION ON SERUM PANCREATIC SECRETORY TRYPSIN INHIBITOR CONCENTRATION

The influence of renal function on serum pancreatic secretory trypsin inhibitor (PSTI) concentration was studied by measuring serum PSTI, creatinine and urea nitrogen (BUN) concentrations in 116 patients with chronic renal failure. Serum PSTI concentration determined by radioimmunoassay was compared with serum creatinine and BUN concentrations, and creatinine clearance. Serum PSTI concentration was markedly elevated in patients with chronic renal failure, more so in patients undergoing hemodialysis. Elevated serum levels of PSTI in chronic renal failure were highly correlated with elevation of both serum creatinine and BUN. In addition, inverse correlation between serum PSTI concentartion and creatinine clearance was observed. The simultaneously high serum levels of PSTI and creatinine strongly suggest that clearance of these substances is reduced in pchronic renal atients with failure. These results indicate that renal function is one of factors that influence serum levels of PSTI. Thus, it is important to consider the renal function before assessing the elevated serum PSTI levels in patients with various diseases.