Detection of colorectal cancer using 18F-FLT PET: comparison with 18F-FDG PET
OBJECTIVEWe investigated the feasibility of 3′-deoxy-3′-F-fluorothymidine (FLT) positron emission tomography (PET) for the detection of colorectal cancer, in comparison with 2-deoxy-2-F-fluoro-D-glucose (FDG) PET, and investigated correlation of the two radiotracers used with proliferative activity...
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| Veröffentlicht in: | Nuclear medicine communications 2009-11, Vol.30 (11), p.841-845 |
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| container_title | Nuclear medicine communications |
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| creator | Yamamoto, Yuka Kameyama, Reiko Izuishi, Kunihiko Takebayashi, Ryusuke Hagiike, Masanobu Asakura, Masato Haba, Reiji Nishiyama, Yoshihiro |
| description | OBJECTIVEWe investigated the feasibility of 3′-deoxy-3′-F-fluorothymidine (FLT) positron emission tomography (PET) for the detection of colorectal cancer, in comparison with 2-deoxy-2-F-fluoro-D-glucose (FDG) PET, and investigated correlation of the two radiotracers used with proliferative activity as indicated by Ki-67 index.
METHODSA total of 26 patients with newly diagnosed colorectal cancer were examined with FLT PET and FDG PET. Tumor lesions were identified as areas of focally increased uptake, exceeding that of surrounding normal tissue. For semiquantitative analysis, the maximal standardized uptake value (SUV) was calculated.
RESULTSIn all 26 patients, colorectal cancers were detected by both FLT PET and FDG PET. The mean (±SD) values of FLT SUV in colon cancer (5.4±2.4) and in rectal cancer (5.6±1.3) were significantly lower than the corresponding values of FDG SUV (12.4±6.3 and 12.5±4.7, respectively) (P |
| doi_str_mv | 10.1097/MNM.0b013e328330294d |
| format | Article |
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METHODSA total of 26 patients with newly diagnosed colorectal cancer were examined with FLT PET and FDG PET. Tumor lesions were identified as areas of focally increased uptake, exceeding that of surrounding normal tissue. For semiquantitative analysis, the maximal standardized uptake value (SUV) was calculated.
RESULTSIn all 26 patients, colorectal cancers were detected by both FLT PET and FDG PET. The mean (±SD) values of FLT SUV in colon cancer (5.4±2.4) and in rectal cancer (5.6±1.3) were significantly lower than the corresponding values of FDG SUV (12.4±6.3 and 12.5±4.7, respectively) (P<0.003). There was no significant correlation between Ki-67 index and either FLT SUV or FDG SUV.
CONCLUSIONAlthough uptake of FLT was found to be significantly lower than that of FDG, both FLT PET and FDG PET were able to detect colorectal cancers in all 26 patients. Neither of the two radiotracers used was correlated with proliferative activity.</description><identifier>ISSN: 0143-3636</identifier><identifier>EISSN: 1473-5628</identifier><identifier>DOI: 10.1097/MNM.0b013e328330294d</identifier><identifier>PMID: 19773672</identifier><language>eng</language><publisher>England: Lippincott Williams & Wilkins, Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Cell Proliferation ; Colorectal Neoplasms - diagnostic imaging ; Colorectal Neoplasms - metabolism ; Colorectal Neoplasms - pathology ; Dideoxynucleosides ; Feasibility Studies ; Female ; Fluorodeoxyglucose F18 ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Positron-Emission Tomography - methods ; Prospective Studies</subject><ispartof>Nuclear medicine communications, 2009-11, Vol.30 (11), p.841-845</ispartof><rights>2009 Lippincott Williams & Wilkins, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1964-1f3953109578c176124e7f4b502d23496dbbad80e8780dbafedac0251e3c89d3</citedby><cites>FETCH-LOGICAL-c1964-1f3953109578c176124e7f4b502d23496dbbad80e8780dbafedac0251e3c89d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19773672$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamamoto, Yuka</creatorcontrib><creatorcontrib>Kameyama, Reiko</creatorcontrib><creatorcontrib>Izuishi, Kunihiko</creatorcontrib><creatorcontrib>Takebayashi, Ryusuke</creatorcontrib><creatorcontrib>Hagiike, Masanobu</creatorcontrib><creatorcontrib>Asakura, Masato</creatorcontrib><creatorcontrib>Haba, Reiji</creatorcontrib><creatorcontrib>Nishiyama, Yoshihiro</creatorcontrib><title>Detection of colorectal cancer using 18F-FLT PET: comparison with 18F-FDG PET</title><title>Nuclear medicine communications</title><addtitle>Nucl Med Commun</addtitle><description>OBJECTIVEWe investigated the feasibility of 3′-deoxy-3′-F-fluorothymidine (FLT) positron emission tomography (PET) for the detection of colorectal cancer, in comparison with 2-deoxy-2-F-fluoro-D-glucose (FDG) PET, and investigated correlation of the two radiotracers used with proliferative activity as indicated by Ki-67 index.
METHODSA total of 26 patients with newly diagnosed colorectal cancer were examined with FLT PET and FDG PET. Tumor lesions were identified as areas of focally increased uptake, exceeding that of surrounding normal tissue. For semiquantitative analysis, the maximal standardized uptake value (SUV) was calculated.
RESULTSIn all 26 patients, colorectal cancers were detected by both FLT PET and FDG PET. The mean (±SD) values of FLT SUV in colon cancer (5.4±2.4) and in rectal cancer (5.6±1.3) were significantly lower than the corresponding values of FDG SUV (12.4±6.3 and 12.5±4.7, respectively) (P<0.003). There was no significant correlation between Ki-67 index and either FLT SUV or FDG SUV.
CONCLUSIONAlthough uptake of FLT was found to be significantly lower than that of FDG, both FLT PET and FDG PET were able to detect colorectal cancers in all 26 patients. Neither of the two radiotracers used was correlated with proliferative activity.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cell Proliferation</subject><subject>Colorectal Neoplasms - diagnostic imaging</subject><subject>Colorectal Neoplasms - metabolism</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Dideoxynucleosides</subject><subject>Feasibility Studies</subject><subject>Female</subject><subject>Fluorodeoxyglucose F18</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Positron-Emission Tomography - methods</subject><subject>Prospective Studies</subject><issn>0143-3636</issn><issn>1473-5628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkMtOwzAQRS0EglL4A4SyYxUYe5zYYYeAAlILLLq3HGdCA2lT7EQVf4-rVkJiNc97R3MYu-BwzaFQN7PX2TWUwJFQaEQQhawO2IhLhWmWC33IRsAlpphjfsJOQ_gEAI25OmYnvFAqZmLEZg_Uk-ubbpV0deK6tvOxtG3i7MqRT4bQrD4SrifpZDpP3h_nt3Fpuba-CVGyafrFbvjwtB2esaPatoHO93HM5pPH-f1zOn17erm_m6aOF7lMeY1FhvGLTGnHVc6FJFXLMgNRCZRFXpWlrTSQVhqq0tZUWQci44ROFxWO2dXOdu2774FCb5ZNcNS2dkXdEIzKtEYpIokxk7tN57sQPNVm7Zul9T-Gg9liNBGj-Y8xyi73B4ZySdWfaM_tz3fTtT358NUOG_JmQbbtFyaChlwgTwVAwXms0m1L4i_KXHsO</recordid><startdate>200911</startdate><enddate>200911</enddate><creator>Yamamoto, Yuka</creator><creator>Kameyama, Reiko</creator><creator>Izuishi, Kunihiko</creator><creator>Takebayashi, Ryusuke</creator><creator>Hagiike, Masanobu</creator><creator>Asakura, Masato</creator><creator>Haba, Reiji</creator><creator>Nishiyama, Yoshihiro</creator><general>Lippincott Williams & Wilkins, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200911</creationdate><title>Detection of colorectal cancer using 18F-FLT PET: comparison with 18F-FDG PET</title><author>Yamamoto, Yuka ; Kameyama, Reiko ; Izuishi, Kunihiko ; Takebayashi, Ryusuke ; Hagiike, Masanobu ; Asakura, Masato ; Haba, Reiji ; Nishiyama, Yoshihiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1964-1f3953109578c176124e7f4b502d23496dbbad80e8780dbafedac0251e3c89d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cell Proliferation</topic><topic>Colorectal Neoplasms - diagnostic imaging</topic><topic>Colorectal Neoplasms - metabolism</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Dideoxynucleosides</topic><topic>Feasibility Studies</topic><topic>Female</topic><topic>Fluorodeoxyglucose F18</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Positron-Emission Tomography - methods</topic><topic>Prospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamamoto, Yuka</creatorcontrib><creatorcontrib>Kameyama, Reiko</creatorcontrib><creatorcontrib>Izuishi, Kunihiko</creatorcontrib><creatorcontrib>Takebayashi, Ryusuke</creatorcontrib><creatorcontrib>Hagiike, Masanobu</creatorcontrib><creatorcontrib>Asakura, Masato</creatorcontrib><creatorcontrib>Haba, Reiji</creatorcontrib><creatorcontrib>Nishiyama, Yoshihiro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nuclear medicine communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamamoto, Yuka</au><au>Kameyama, Reiko</au><au>Izuishi, Kunihiko</au><au>Takebayashi, Ryusuke</au><au>Hagiike, Masanobu</au><au>Asakura, Masato</au><au>Haba, Reiji</au><au>Nishiyama, Yoshihiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Detection of colorectal cancer using 18F-FLT PET: comparison with 18F-FDG PET</atitle><jtitle>Nuclear medicine communications</jtitle><addtitle>Nucl Med Commun</addtitle><date>2009-11</date><risdate>2009</risdate><volume>30</volume><issue>11</issue><spage>841</spage><epage>845</epage><pages>841-845</pages><issn>0143-3636</issn><eissn>1473-5628</eissn><abstract>OBJECTIVEWe investigated the feasibility of 3′-deoxy-3′-F-fluorothymidine (FLT) positron emission tomography (PET) for the detection of colorectal cancer, in comparison with 2-deoxy-2-F-fluoro-D-glucose (FDG) PET, and investigated correlation of the two radiotracers used with proliferative activity as indicated by Ki-67 index.
METHODSA total of 26 patients with newly diagnosed colorectal cancer were examined with FLT PET and FDG PET. Tumor lesions were identified as areas of focally increased uptake, exceeding that of surrounding normal tissue. For semiquantitative analysis, the maximal standardized uptake value (SUV) was calculated.
RESULTSIn all 26 patients, colorectal cancers were detected by both FLT PET and FDG PET. The mean (±SD) values of FLT SUV in colon cancer (5.4±2.4) and in rectal cancer (5.6±1.3) were significantly lower than the corresponding values of FDG SUV (12.4±6.3 and 12.5±4.7, respectively) (P<0.003). There was no significant correlation between Ki-67 index and either FLT SUV or FDG SUV.
CONCLUSIONAlthough uptake of FLT was found to be significantly lower than that of FDG, both FLT PET and FDG PET were able to detect colorectal cancers in all 26 patients. Neither of the two radiotracers used was correlated with proliferative activity.</abstract><cop>England</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>19773672</pmid><doi>10.1097/MNM.0b013e328330294d</doi><tpages>5</tpages></addata></record> |
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| ispartof | Nuclear medicine communications, 2009-11, Vol.30 (11), p.841-845 |
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| source | Journals@Ovid Ovid Autoload; MEDLINE |
| subjects | Adult Aged Aged, 80 and over Cell Proliferation Colorectal Neoplasms - diagnostic imaging Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Dideoxynucleosides Feasibility Studies Female Fluorodeoxyglucose F18 Humans Immunohistochemistry Male Middle Aged Positron-Emission Tomography - methods Prospective Studies |
| title | Detection of colorectal cancer using 18F-FLT PET: comparison with 18F-FDG PET |
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