SPENOLIMYCIN, A NEW SPECTINOMYCIN-TYPE ANTIBIOTIC: III. BIOLOGICAL PROPERTIES

Spenolimycin is a new spectinomycin-type antibiotic isolated from Streptomyces gilvospiralis sp. nov. In vitro, it was active against a wide variety of aerobic Gram-positive and Gramnegative bacteria and Neisseria gonorrhoeae. It was two to four-fold more active against N. gonorrhoeae than spectinom...

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Veröffentlicht in:	Journal of antibiotics 1984, Vol.37(12), pp.1525-1527
Hauptverfasser:	FERNANDES, PRABHAVATHI B., VOJTKO, CHARLENE M., BOWER, ROBERT R., WEISZ, JONINA
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Bacterial Infections - prevention & control Biological and medical sciences Female Medical sciences Mice Mice, Inbred Strains Microbial Sensitivity Tests Neisseria gonorrhoeae Neisseria gonorrhoeae - drug effects Pharmacology. Drug treatments Spectinomycin - analogs & derivatives Spectinomycin - pharmacology
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Beschreibung
Zusammenfassung:	Spenolimycin is a new spectinomycin-type antibiotic isolated from Streptomyces gilvospiralis sp. nov. In vitro, it was active against a wide variety of aerobic Gram-positive and Gramnegative bacteria and Neisseria gonorrhoeae. It was two to four-fold more active against N. gonorrhoeae than spectinomycin. Spenolimycin was effective in the standard mouse protection test against Escherichia coli, Klebsiella pneumoniae and Streptococcus pneumoniae.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.37.1525