Terminal acute myelogenous leukemia in a patient with congenital agranulocytosis

Congenital agranulocytosis terminating in acute myelogenous leukemia has been previously reported in only two cases of adolescent males. We describe the clinical and laboratory features of a 13‐year‐old male with congenital agranulocytosis, treated with G‐CSF with initial good neutrophil response, w...

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Veröffentlicht in:American journal of hematology 1993-06, Vol.43 (2), p.133-138
Hauptverfasser: Wong, Wing‐Yen, Williams, Donald, Slovak, Marilyn L., Charak, Bishan, Mazumder, Amitabha, Snyder, David, Powars, Darleen R., Brynes, Russell K.
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Sprache:eng
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Zusammenfassung:Congenital agranulocytosis terminating in acute myelogenous leukemia has been previously reported in only two cases of adolescent males. We describe the clinical and laboratory features of a 13‐year‐old male with congenital agranulocytosis, treated with G‐CSF with initial good neutrophil response, who subsequently developed acute myeloid leukemia. This rare complication may define a preleukemic subset of patients for whom G‐CSF therapy is ineffective. The diagnostic challenges of this case are presented.
ISSN:0361-8609
1096-8652
DOI:10.1002/ajh.2830430212