Doppler quantification of echo-contrast injections in vivo

It is difficult to quantify myocardial perfusion using contrast echocardiography because the echogenicity of injected contrast is unknown. We propose that a measurement of Doppler amplitude from blood in a systemic artery during the passage of contrast could define the needed input function. Time-am...

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Veröffentlicht in:Ultrasound in medicine & biology 1993, Vol.19 (4), p.269-278
Hauptverfasser: Hartley, Craig J., Cheirif, Jorge, Collier, Kevin R., Stanley Bravenec, J., Mickelson, Judith K.
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Sprache:eng
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Zusammenfassung:It is difficult to quantify myocardial perfusion using contrast echocardiography because the echogenicity of injected contrast is unknown. We propose that a measurement of Doppler amplitude from blood in a systemic artery during the passage of contrast could define the needed input function. Time-amplitude curves from pulsed Doppler cuffs on coronary and carotid arteries of 7 dogs were analyzed during aortic root and left atrial injections of Albunex ®. We found in individual animals that the areas under the Doppler time-amplitude curves were correlated to the amount of Albunex ® injected ( R = 0.87–0.99), inversely correlated to cardiac output ( R = 0.83), and uncorrelated to coronary flow ( R = 0.18). Due to better mixing, the coronary and carotid response areas correlated better for left atrial injections ( R = 0.96) than for aortic root injections ( R = 0.56). We conclude that Doppler amplitude detection can be used to quantify the passage of echo-contrast agents, that the measurements comply with indicator-dilution principles, and that systemic measurements in the carotid artery could be used to predict the coronary input function for injection sites with good systemic mixing.
ISSN:0301-5629
1879-291X
DOI:10.1016/0301-5629(93)90099-A