Doppler quantification of echo-contrast injections in vivo
It is difficult to quantify myocardial perfusion using contrast echocardiography because the echogenicity of injected contrast is unknown. We propose that a measurement of Doppler amplitude from blood in a systemic artery during the passage of contrast could define the needed input function. Time-am...
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Veröffentlicht in: | Ultrasound in medicine & biology 1993, Vol.19 (4), p.269-278 |
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Sprache: | eng |
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Zusammenfassung: | It is difficult to quantify myocardial perfusion using contrast echocardiography because the echogenicity of injected contrast is unknown. We propose that a measurement of Doppler amplitude from blood in a systemic artery during the passage of contrast could define the needed input function. Time-amplitude curves from pulsed Doppler cuffs on coronary and carotid arteries of 7 dogs were analyzed during aortic root and left atrial injections of Albunex
®. We found in individual animals that the areas under the Doppler time-amplitude curves were correlated to the amount of Albunex
® injected (
R = 0.87–0.99), inversely correlated to cardiac output (
R = 0.83), and uncorrelated to coronary flow (
R = 0.18). Due to better mixing, the coronary and carotid response areas correlated better for left atrial injections (
R = 0.96) than for aortic root injections (
R = 0.56). We conclude that Doppler amplitude detection can be used to quantify the passage of echo-contrast agents, that the measurements comply with indicator-dilution principles, and that systemic measurements in the carotid artery could be used to predict the coronary input function for injection sites with good systemic mixing. |
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ISSN: | 0301-5629 1879-291X |
DOI: | 10.1016/0301-5629(93)90099-A |