LAGUNAMYCIN, A NOVEL 5-LIPOXYGENASE INHIBITOR: I. TAXONOMY, FERMENTATION, PHYSICO-CHEMICAL PROPERTIES AND BIOLOGICAL CHARACTERISTICS
Lagunamycin, a novel 5-lipoxygenase inhibitor, was isolated from the culture broth of Streptomyces sp. AA0310. This compound showed potent rat 5-lipoxygenase inhibitory activity (IC50 6.08μM) without lipid peroxidation.
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| Veröffentlicht in: | Journal of antibiotics 1993/06/25, Vol.46(6), pp.900-907 |
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| container_end_page | 907 |
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| container_issue | 6 |
| container_start_page | 900 |
| container_title | Journal of antibiotics |
| container_volume | 46 |
| creator | NIHEI, YOSHIMI HASEGAWA, MASAMI SUZUKI, KIYOSHI YAMAMOTO, SATOSHI HANADA, MINORU FURUMAI, TAMOTSU FUKAGAWA, YASUO OKI, TOSHIKAZU |
| description | Lagunamycin, a novel 5-lipoxygenase inhibitor, was isolated from the culture broth of Streptomyces sp. AA0310. This compound showed potent rat 5-lipoxygenase inhibitory activity (IC50 6.08μM) without lipid peroxidation. |
| doi_str_mv | 10.7164/antibiotics.46.900 |
| format | Article |
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TAXONOMY, FERMENTATION, PHYSICO-CHEMICAL PROPERTIES AND BIOLOGICAL CHARACTERISTICS</title><title>Journal of antibiotics</title><addtitle>J. Antibiot.</addtitle><description>Lagunamycin, a novel 5-lipoxygenase inhibitor, was isolated from the culture broth of Streptomyces sp. AA0310. This compound showed potent rat 5-lipoxygenase inhibitory activity (IC50 6.08μM) without lipid peroxidation.</description><subject>Animals</subject><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - isolation & purification</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Biological and medical sciences</subject><subject>Cells, Cultured</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Diazonium Compounds - chemistry</subject><subject>Diazonium Compounds - isolation & purification</subject><subject>Diazonium Compounds - pharmacology</subject><subject>Fermentation</subject><subject>Lipoxygenase Inhibitors</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Microbial Sensitivity Tests</subject><subject>Pharmacology. Drug treatments</subject><subject>Quinolones - chemistry</subject><subject>Quinolones - isolation & purification</subject><subject>Quinolones - pharmacology</subject><subject>Streptomyces</subject><subject>Streptomyces - chemistry</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtPwkAUhSdGg4j-ARMTFsaVxTszndeyEoTGWoyCkdVkOky1pDzswMJ_bwmEsHNz7-J8556bg9A1ho7APHwwi3WRFct1YX0n5B0FcIKaWEoc4JCrU9QEIDiQksA5uvB-BkAFFbKBGpIqKhk0UZBE_XEavUy6cXrfjtrp8KOXtFmQxK_Dz0m_l0bvvXacDuLHeDR8u0RnuSm9u9rvFho_9UbdQZAM-3E3SgIbMgwBUSBYLhnJhBOESj4lzJrcKaIyHjJFiGLZ1BJiGZOS5pAZCzRTJM-xmRJFW-hud3dVLX82zq_1vPDWlaVZuOXGa1HbgDP2L4gFhIyDrEGyA2219L5yuV5VxdxUvxqD3papj8rUIdd1mbXpZn99k83d9GDZt1frt3vdeGvKvDILW_gDFkopgG-x5x0282vz5Q66qeqw0h0nY8XlNp3vRv3EgbLfptJuQf8A9_OUxQ</recordid><startdate>1993</startdate><enddate>1993</enddate><creator>NIHEI, YOSHIMI</creator><creator>HASEGAWA, MASAMI</creator><creator>SUZUKI, KIYOSHI</creator><creator>YAMAMOTO, SATOSHI</creator><creator>HANADA, MINORU</creator><creator>FURUMAI, TAMOTSU</creator><creator>FUKAGAWA, YASUO</creator><creator>OKI, TOSHIKAZU</creator><general>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</general><general>Japan Antibiotics Research Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>1993</creationdate><title>LAGUNAMYCIN, A NOVEL 5-LIPOXYGENASE INHIBITOR</title><author>NIHEI, YOSHIMI ; HASEGAWA, MASAMI ; SUZUKI, KIYOSHI ; YAMAMOTO, SATOSHI ; HANADA, MINORU ; FURUMAI, TAMOTSU ; FUKAGAWA, YASUO ; OKI, TOSHIKAZU</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4510-29075f852b7e72386d25cafe929b64592295bdc22c55883f0bac03b92ff1ad293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Anti-Bacterial Agents - chemistry</topic><topic>Anti-Bacterial Agents - isolation & purification</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibacterial agents</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Biological and medical sciences</topic><topic>Cells, Cultured</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Diazonium Compounds - chemistry</topic><topic>Diazonium Compounds - isolation & purification</topic><topic>Diazonium Compounds - pharmacology</topic><topic>Fermentation</topic><topic>Lipoxygenase Inhibitors</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Microbial Sensitivity Tests</topic><topic>Pharmacology. 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TAXONOMY, FERMENTATION, PHYSICO-CHEMICAL PROPERTIES AND BIOLOGICAL CHARACTERISTICS</atitle><jtitle>Journal of antibiotics</jtitle><addtitle>J. Antibiot.</addtitle><date>1993</date><risdate>1993</risdate><volume>46</volume><issue>6</issue><spage>900</spage><epage>907</epage><pages>900-907</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><coden>JANTAJ</coden><abstract>Lagunamycin, a novel 5-lipoxygenase inhibitor, was isolated from the culture broth of Streptomyces sp. AA0310. This compound showed potent rat 5-lipoxygenase inhibitory activity (IC50 6.08μM) without lipid peroxidation.</abstract><cop>Tokyo</cop><pub>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</pub><pmid>8393850</pmid><doi>10.7164/antibiotics.46.900</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-8820 |
| ispartof | The Journal of Antibiotics, 1993/06/25, Vol.46(6), pp.900-907 |
| issn | 0021-8820 1881-1469 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75880655 |
| source | J-STAGE Free; MEDLINE |
| subjects | Animals Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Cells, Cultured Chromatography, High Pressure Liquid Diazonium Compounds - chemistry Diazonium Compounds - isolation & purification Diazonium Compounds - pharmacology Fermentation Lipoxygenase Inhibitors Medical sciences Mice Microbial Sensitivity Tests Pharmacology. Drug treatments Quinolones - chemistry Quinolones - isolation & purification Quinolones - pharmacology Streptomyces Streptomyces - chemistry |
| title | LAGUNAMYCIN, A NOVEL 5-LIPOXYGENASE INHIBITOR: I. TAXONOMY, FERMENTATION, PHYSICO-CHEMICAL PROPERTIES AND BIOLOGICAL CHARACTERISTICS |
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