LAGUNAMYCIN, A NOVEL 5-LIPOXYGENASE INHIBITOR: I. TAXONOMY, FERMENTATION, PHYSICO-CHEMICAL PROPERTIES AND BIOLOGICAL CHARACTERISTICS

Lagunamycin, a novel 5-lipoxygenase inhibitor, was isolated from the culture broth of Streptomyces sp. AA0310. This compound showed potent rat 5-lipoxygenase inhibitory activity (IC50 6.08μM) without lipid peroxidation.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of antibiotics 1993/06/25, Vol.46(6), pp.900-907
Hauptverfasser:	NIHEI, YOSHIMI, HASEGAWA, MASAMI, SUZUKI, KIYOSHI, YAMAMOTO, SATOSHI, HANADA, MINORU, FURUMAI, TAMOTSU, FUKAGAWA, YASUO, OKI, TOSHIKAZU
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Cells, Cultured Chromatography, High Pressure Liquid Diazonium Compounds - chemistry Diazonium Compounds - isolation & purification Diazonium Compounds - pharmacology Fermentation Lipoxygenase Inhibitors Medical sciences Mice Microbial Sensitivity Tests Pharmacology. Drug treatments Quinolones - chemistry Quinolones - isolation & purification Quinolones - pharmacology Streptomyces Streptomyces - chemistry
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Beschreibung
Zusammenfassung:	Lagunamycin, a novel 5-lipoxygenase inhibitor, was isolated from the culture broth of Streptomyces sp. AA0310. This compound showed potent rat 5-lipoxygenase inhibitory activity (IC50 6.08μM) without lipid peroxidation.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.46.900