Adhesion of Cerebral Endothelial Cells to Lymphocytes from Patients with Multiple Sclerosis
To investigate the factors regulating the entry of lymphocytes into the brain, we assessed the adhesion in vitro of 51Cr labelled lymphocytes from peripheral blood of patients with multiple sclerosis (MS) to human cerebral endothelial cells, and evaluated the effect on the adhesion of endothelium ac...
Gespeichert in:
Veröffentlicht in: | Autoimmunity (Chur, Switzerland) Switzerland), 1993, Vol.14 (4), p.329-333 |
---|---|
Hauptverfasser: | , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 333 |
---|---|
container_issue | 4 |
container_start_page | 329 |
container_title | Autoimmunity (Chur, Switzerland) |
container_volume | 14 |
creator | Tsukada, Naoyuki Matsuda, Masayuki Miyagi, Koichi Yanagisawa, Nobuo |
description | To investigate the factors regulating the entry of lymphocytes into the brain, we assessed the adhesion in vitro of 51Cr labelled lymphocytes from peripheral blood of patients with multiple sclerosis (MS) to human cerebral endothelial cells, and evaluated the effect on the adhesion of endothelium activated by interferon-γ (IFN-γ). lipopolysaccharides (LPS), interleukin-1 (IL-1) and tumor necrosis factor (TNF). Patients with acute relapsing MS during an exacerbation showed significant increase in MNC adherence to cerebral. endothelial cells as compared with controls (p |
doi_str_mv | 10.3109/08916939309079236 |
format | Article |
fullrecord | <record><control><sourceid>proquest_infor</sourceid><recordid>TN_cdi_proquest_miscellaneous_75876848</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>75876848</sourcerecordid><originalsourceid>FETCH-LOGICAL-c430t-de90526986c350afb2c2083c8a3b4f1565658110537e8a80716abb555f909d893</originalsourceid><addsrcrecordid>eNp9kEuLFDEUhYMoYzv6A1wIWYi70qTyRjdDMz6gRUEFwUWRSt2iMqQqbZJi6H9vmm4HRBjuIhfOdy4nB6HnlLxmlJg3RBsqDTOMGKJMy-QDtKGSqEbz9udDtDnqTQX4Y_Qk5xtCSKskv0AXmnGllNigX1fDBNnHBccRbyFBn2zA18sQywTB130LIWRcIt4d5v0U3aFAxmOKM_5qi4elZHzry4Q_r6H4fQD8zQVIMfv8FD0abcjw7Pxeoh_vr79vPza7Lx8-ba92jeOMlGYAQ0QrjZaOCWLHvnUt0cxpy3o-UiHraEqJYAq01URRafteCDEaYgZt2CV6dbq7T_H3Crl0s8-uxrYLxDV3SmglNdcVpCfQ1Xw5wdjtk59tOnSUdMdCu_8KrZ4X5-NrP8Nw5zg3WPWXZ91mZ8OY7OJ8vsO4VsLwY8Z3J8wvY0yzvY0pDF2xhxDTXw-7L8Xbf-wT2FAmZxN0N3FNS633nj_8AVKsolo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>75876848</pqid></control><display><type>article</type><title>Adhesion of Cerebral Endothelial Cells to Lymphocytes from Patients with Multiple Sclerosis</title><source>MEDLINE</source><source>Taylor & Francis Journals Complete</source><creator>Tsukada, Naoyuki ; Matsuda, Masayuki ; Miyagi, Koichi ; Yanagisawa, Nobuo</creator><creatorcontrib>Tsukada, Naoyuki ; Matsuda, Masayuki ; Miyagi, Koichi ; Yanagisawa, Nobuo</creatorcontrib><description>To investigate the factors regulating the entry of lymphocytes into the brain, we assessed the adhesion in vitro of 51Cr labelled lymphocytes from peripheral blood of patients with multiple sclerosis (MS) to human cerebral endothelial cells, and evaluated the effect on the adhesion of endothelium activated by interferon-γ (IFN-γ). lipopolysaccharides (LPS), interleukin-1 (IL-1) and tumor necrosis factor (TNF). Patients with acute relapsing MS during an exacerbation showed significant increase in MNC adherence to cerebral. endothelial cells as compared with controls (p<0.001). MNC adherence to cerebral endothelial cells activated by IFN-γ or LPS, was significantly increased as compared to the controls (p<0.01). MNC adherence to endothelial cells was not blocked by antibodies against the intercellular adhesion molecule-1 (ICAM-1), but was blocked by lymphocyte function-associated antigen-1 (LFA-1). The increased adherence observed in patients with acute relapsing MS during an exacerbation would modulate the migration of lymphocytes across the blood-brain barrier (BBB).</description><identifier>ISSN: 0891-6934</identifier><identifier>EISSN: 1607-842X</identifier><identifier>DOI: 10.3109/08916939309079236</identifier><identifier>PMID: 8347775</identifier><language>eng</language><publisher>Abingdon: Informa UK Ltd</publisher><subject>Adolescent ; Adult ; Antibodies, Monoclonal - immunology ; Biological and medical sciences ; Brain - cytology ; Cell Adhesion - drug effects ; Cell Adhesion Molecules - physiology ; Cytokines - pharmacology ; Endothelium, Vascular - cytology ; Endothelium, Vascular - physiology ; Female ; Humans ; Lymphocytes - physiology ; Male ; Medical sciences ; Middle Aged ; Multiple Sclerosis - immunology ; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis ; Neurology</subject><ispartof>Autoimmunity (Chur, Switzerland), 1993, Vol.14 (4), p.329-333</ispartof><rights>1993 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1993</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-de90526986c350afb2c2083c8a3b4f1565658110537e8a80716abb555f909d893</citedby><cites>FETCH-LOGICAL-c430t-de90526986c350afb2c2083c8a3b4f1565658110537e8a80716abb555f909d893</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/08916939309079236$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/08916939309079236$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,778,782,4012,27906,27907,27908,59628,60417,61202,61383</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4875949$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8347775$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tsukada, Naoyuki</creatorcontrib><creatorcontrib>Matsuda, Masayuki</creatorcontrib><creatorcontrib>Miyagi, Koichi</creatorcontrib><creatorcontrib>Yanagisawa, Nobuo</creatorcontrib><title>Adhesion of Cerebral Endothelial Cells to Lymphocytes from Patients with Multiple Sclerosis</title><title>Autoimmunity (Chur, Switzerland)</title><addtitle>Autoimmunity</addtitle><description>To investigate the factors regulating the entry of lymphocytes into the brain, we assessed the adhesion in vitro of 51Cr labelled lymphocytes from peripheral blood of patients with multiple sclerosis (MS) to human cerebral endothelial cells, and evaluated the effect on the adhesion of endothelium activated by interferon-γ (IFN-γ). lipopolysaccharides (LPS), interleukin-1 (IL-1) and tumor necrosis factor (TNF). Patients with acute relapsing MS during an exacerbation showed significant increase in MNC adherence to cerebral. endothelial cells as compared with controls (p<0.001). MNC adherence to cerebral endothelial cells activated by IFN-γ or LPS, was significantly increased as compared to the controls (p<0.01). MNC adherence to endothelial cells was not blocked by antibodies against the intercellular adhesion molecule-1 (ICAM-1), but was blocked by lymphocyte function-associated antigen-1 (LFA-1). The increased adherence observed in patients with acute relapsing MS during an exacerbation would modulate the migration of lymphocytes across the blood-brain barrier (BBB).</description><subject>Adolescent</subject><subject>Adult</subject><subject>Antibodies, Monoclonal - immunology</subject><subject>Biological and medical sciences</subject><subject>Brain - cytology</subject><subject>Cell Adhesion - drug effects</subject><subject>Cell Adhesion Molecules - physiology</subject><subject>Cytokines - pharmacology</subject><subject>Endothelium, Vascular - cytology</subject><subject>Endothelium, Vascular - physiology</subject><subject>Female</subject><subject>Humans</subject><subject>Lymphocytes - physiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multiple Sclerosis - immunology</subject><subject>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</subject><subject>Neurology</subject><issn>0891-6934</issn><issn>1607-842X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEuLFDEUhYMoYzv6A1wIWYi70qTyRjdDMz6gRUEFwUWRSt2iMqQqbZJi6H9vmm4HRBjuIhfOdy4nB6HnlLxmlJg3RBsqDTOMGKJMy-QDtKGSqEbz9udDtDnqTQX4Y_Qk5xtCSKskv0AXmnGllNigX1fDBNnHBccRbyFBn2zA18sQywTB130LIWRcIt4d5v0U3aFAxmOKM_5qi4elZHzry4Q_r6H4fQD8zQVIMfv8FD0abcjw7Pxeoh_vr79vPza7Lx8-ba92jeOMlGYAQ0QrjZaOCWLHvnUt0cxpy3o-UiHraEqJYAq01URRafteCDEaYgZt2CV6dbq7T_H3Crl0s8-uxrYLxDV3SmglNdcVpCfQ1Xw5wdjtk59tOnSUdMdCu_8KrZ4X5-NrP8Nw5zg3WPWXZ91mZ8OY7OJ8vsO4VsLwY8Z3J8wvY0yzvY0pDF2xhxDTXw-7L8Xbf-wT2FAmZxN0N3FNS633nj_8AVKsolo</recordid><startdate>1993</startdate><enddate>1993</enddate><creator>Tsukada, Naoyuki</creator><creator>Matsuda, Masayuki</creator><creator>Miyagi, Koichi</creator><creator>Yanagisawa, Nobuo</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Taylor and Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1993</creationdate><title>Adhesion of Cerebral Endothelial Cells to Lymphocytes from Patients with Multiple Sclerosis</title><author>Tsukada, Naoyuki ; Matsuda, Masayuki ; Miyagi, Koichi ; Yanagisawa, Nobuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-de90526986c350afb2c2083c8a3b4f1565658110537e8a80716abb555f909d893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Antibodies, Monoclonal - immunology</topic><topic>Biological and medical sciences</topic><topic>Brain - cytology</topic><topic>Cell Adhesion - drug effects</topic><topic>Cell Adhesion Molecules - physiology</topic><topic>Cytokines - pharmacology</topic><topic>Endothelium, Vascular - cytology</topic><topic>Endothelium, Vascular - physiology</topic><topic>Female</topic><topic>Humans</topic><topic>Lymphocytes - physiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multiple Sclerosis - immunology</topic><topic>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</topic><topic>Neurology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tsukada, Naoyuki</creatorcontrib><creatorcontrib>Matsuda, Masayuki</creatorcontrib><creatorcontrib>Miyagi, Koichi</creatorcontrib><creatorcontrib>Yanagisawa, Nobuo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Autoimmunity (Chur, Switzerland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tsukada, Naoyuki</au><au>Matsuda, Masayuki</au><au>Miyagi, Koichi</au><au>Yanagisawa, Nobuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adhesion of Cerebral Endothelial Cells to Lymphocytes from Patients with Multiple Sclerosis</atitle><jtitle>Autoimmunity (Chur, Switzerland)</jtitle><addtitle>Autoimmunity</addtitle><date>1993</date><risdate>1993</risdate><volume>14</volume><issue>4</issue><spage>329</spage><epage>333</epage><pages>329-333</pages><issn>0891-6934</issn><eissn>1607-842X</eissn><abstract>To investigate the factors regulating the entry of lymphocytes into the brain, we assessed the adhesion in vitro of 51Cr labelled lymphocytes from peripheral blood of patients with multiple sclerosis (MS) to human cerebral endothelial cells, and evaluated the effect on the adhesion of endothelium activated by interferon-γ (IFN-γ). lipopolysaccharides (LPS), interleukin-1 (IL-1) and tumor necrosis factor (TNF). Patients with acute relapsing MS during an exacerbation showed significant increase in MNC adherence to cerebral. endothelial cells as compared with controls (p<0.001). MNC adherence to cerebral endothelial cells activated by IFN-γ or LPS, was significantly increased as compared to the controls (p<0.01). MNC adherence to endothelial cells was not blocked by antibodies against the intercellular adhesion molecule-1 (ICAM-1), but was blocked by lymphocyte function-associated antigen-1 (LFA-1). The increased adherence observed in patients with acute relapsing MS during an exacerbation would modulate the migration of lymphocytes across the blood-brain barrier (BBB).</abstract><cop>Abingdon</cop><pub>Informa UK Ltd</pub><pmid>8347775</pmid><doi>10.3109/08916939309079236</doi><tpages>5</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0891-6934 |
ispartof | Autoimmunity (Chur, Switzerland), 1993, Vol.14 (4), p.329-333 |
issn | 0891-6934 1607-842X |
language | eng |
recordid | cdi_proquest_miscellaneous_75876848 |
source | MEDLINE; Taylor & Francis Journals Complete |
subjects | Adolescent Adult Antibodies, Monoclonal - immunology Biological and medical sciences Brain - cytology Cell Adhesion - drug effects Cell Adhesion Molecules - physiology Cytokines - pharmacology Endothelium, Vascular - cytology Endothelium, Vascular - physiology Female Humans Lymphocytes - physiology Male Medical sciences Middle Aged Multiple Sclerosis - immunology Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Neurology |
title | Adhesion of Cerebral Endothelial Cells to Lymphocytes from Patients with Multiple Sclerosis |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T09%3A06%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_infor&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Adhesion%20of%20Cerebral%20Endothelial%20Cells%20to%20Lymphocytes%20from%20Patients%20with%20Multiple%20Sclerosis&rft.jtitle=Autoimmunity%20(Chur,%20Switzerland)&rft.au=Tsukada,%20Naoyuki&rft.date=1993&rft.volume=14&rft.issue=4&rft.spage=329&rft.epage=333&rft.pages=329-333&rft.issn=0891-6934&rft.eissn=1607-842X&rft_id=info:doi/10.3109/08916939309079236&rft_dat=%3Cproquest_infor%3E75876848%3C/proquest_infor%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=75876848&rft_id=info:pmid/8347775&rfr_iscdi=true |