Adhesion of Cerebral Endothelial Cells to Lymphocytes from Patients with Multiple Sclerosis

To investigate the factors regulating the entry of lymphocytes into the brain, we assessed the adhesion in vitro of 51Cr labelled lymphocytes from peripheral blood of patients with multiple sclerosis (MS) to human cerebral endothelial cells, and evaluated the effect on the adhesion of endothelium ac...

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Veröffentlicht in:	Autoimmunity (Chur, Switzerland) Switzerland), 1993, Vol.14 (4), p.329-333
Hauptverfasser:	Tsukada, Naoyuki, Matsuda, Masayuki, Miyagi, Koichi, Yanagisawa, Nobuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Antibodies, Monoclonal - immunology Biological and medical sciences Brain - cytology Cell Adhesion - drug effects Cell Adhesion Molecules - physiology Cytokines - pharmacology Endothelium, Vascular - cytology Endothelium, Vascular - physiology Female Humans Lymphocytes - physiology Male Medical sciences Middle Aged Multiple Sclerosis - immunology Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Neurology
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Zusammenfassung:	To investigate the factors regulating the entry of lymphocytes into the brain, we assessed the adhesion in vitro of 51Cr labelled lymphocytes from peripheral blood of patients with multiple sclerosis (MS) to human cerebral endothelial cells, and evaluated the effect on the adhesion of endothelium activated by interferon-γ (IFN-γ). lipopolysaccharides (LPS), interleukin-1 (IL-1) and tumor necrosis factor (TNF). Patients with acute relapsing MS during an exacerbation showed significant increase in MNC adherence to cerebral. endothelial cells as compared with controls (p
ISSN:	0891-6934 1607-842X
DOI:	10.3109/08916939309079236