Metal Compounds in Therapy and Diagnosis
There is increasing interest in the use of metal-containing compounds in medicine. This review describes several therapeutic applications, such as the use of platinum complexes in cancer chemotherapy, gold compounds in the treatment of arthritis, gallium in hypercalcemia, bismuth in anti-ulcer medic...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1993-08, Vol.261 (5122), p.725-730 |
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| container_issue | 5122 |
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| container_title | Science (American Association for the Advancement of Science) |
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| creator | Abrams, Michael J. Murrer, Barry A. |
| description | There is increasing interest in the use of metal-containing compounds in medicine. This review describes several therapeutic applications, such as the use of platinum complexes in cancer chemotherapy, gold compounds in the treatment of arthritis, gallium in hypercalcemia, bismuth in anti-ulcer medication, and sodium nitroprusside in hypertension. The use of metal radionuclides in diagnosis and radiotherapy and the role of paramagnetic metal complexes as contrast agents in magnetic resonance imaging are also discussed. |
| doi_str_mv | 10.1126/science.8102010 |
| format | Article |
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This review describes several therapeutic applications, such as the use of platinum complexes in cancer chemotherapy, gold compounds in the treatment of arthritis, gallium in hypercalcemia, bismuth in anti-ulcer medication, and sodium nitroprusside in hypertension. The use of metal radionuclides in diagnosis and radiotherapy and the role of paramagnetic metal complexes as contrast agents in magnetic resonance imaging are also discussed.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.8102010</identifier><identifier>PMID: 8102010</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Society for the Advancement of Science</publisher><subject>Anti-Ulcer Agents - therapeutic use ; Antineoplastic Agents - therapeutic use ; Antirheumatic Agents - therapeutic use ; Arthritis ; Arthritis - drug therapy ; Bioinorganic Chemistry ; Biological and medical sciences ; Bismuth ; Bones ; Cancer ; Chemotherapy ; Citrates ; Contrast media ; Diagnostic Imaging ; Drug therapy ; Gallium ; Gallium compounds ; Gold compounds ; Health aspects ; Health care ; Humans ; Hypercalcemia ; Hypercalcemia - drug therapy ; Hypertension ; Imaging ; Materials ; Medical sciences ; Medical treatment ; Metal compounds ; Metal ions ; Metals ; Miscellaneous ; Narcotics ; Nitric Oxide - metabolism ; Nitroprusside ; Nitroprusside - metabolism ; Nitroprusside - therapeutic use ; NMR ; Nuclear magnetic resonance ; Organic Chemistry ; Organogold Compounds ; Organometallic Compounds - therapeutic use ; Oxides ; Patients ; Pharmacology. Drug treatments ; Physical Characteristics ; Platinum ; Platinum compounds ; Radioisotopes - therapeutic use ; Sexually Transmitted Diseases ; Sodium nitroferricyanide ; Technetium ; Tumors ; Ulcers ; Vasodilator Agents - therapeutic use</subject><ispartof>Science (American Association for the Advancement of Science), 1993-08, Vol.261 (5122), p.725-730</ispartof><rights>Copyright 1993 American Association for the Advancement of Science</rights><rights>1993 INIST-CNRS</rights><rights>COPYRIGHT 1993 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Aug 6, 1993</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c736t-a475d8dfc675c2d1690eca7d4dc23fd8829bcfe5bcbeebcc8c9f4538638e2d9f3</citedby><cites>FETCH-LOGICAL-c736t-a475d8dfc675c2d1690eca7d4dc23fd8829bcfe5bcbeebcc8c9f4538638e2d9f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2882236$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2882236$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2870,2871,27903,27904,57995,58228</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4871969$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8102010$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abrams, Michael J.</creatorcontrib><creatorcontrib>Murrer, Barry A.</creatorcontrib><title>Metal Compounds in Therapy and Diagnosis</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>There is increasing interest in the use of metal-containing compounds in medicine. This review describes several therapeutic applications, such as the use of platinum complexes in cancer chemotherapy, gold compounds in the treatment of arthritis, gallium in hypercalcemia, bismuth in anti-ulcer medication, and sodium nitroprusside in hypertension. The use of metal radionuclides in diagnosis and radiotherapy and the role of paramagnetic metal complexes as contrast agents in magnetic resonance imaging are also discussed.</description><subject>Anti-Ulcer Agents - therapeutic use</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Antirheumatic Agents - therapeutic use</subject><subject>Arthritis</subject><subject>Arthritis - drug therapy</subject><subject>Bioinorganic Chemistry</subject><subject>Biological and medical sciences</subject><subject>Bismuth</subject><subject>Bones</subject><subject>Cancer</subject><subject>Chemotherapy</subject><subject>Citrates</subject><subject>Contrast media</subject><subject>Diagnostic Imaging</subject><subject>Drug therapy</subject><subject>Gallium</subject><subject>Gallium compounds</subject><subject>Gold compounds</subject><subject>Health aspects</subject><subject>Health care</subject><subject>Humans</subject><subject>Hypercalcemia</subject><subject>Hypercalcemia - drug therapy</subject><subject>Hypertension</subject><subject>Imaging</subject><subject>Materials</subject><subject>Medical sciences</subject><subject>Medical treatment</subject><subject>Metal compounds</subject><subject>Metal ions</subject><subject>Metals</subject><subject>Miscellaneous</subject><subject>Narcotics</subject><subject>Nitric Oxide - metabolism</subject><subject>Nitroprusside</subject><subject>Nitroprusside - metabolism</subject><subject>Nitroprusside - therapeutic use</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Organic Chemistry</subject><subject>Organogold Compounds</subject><subject>Organometallic Compounds - therapeutic use</subject><subject>Oxides</subject><subject>Patients</subject><subject>Pharmacology. Drug treatments</subject><subject>Physical Characteristics</subject><subject>Platinum</subject><subject>Platinum compounds</subject><subject>Radioisotopes - therapeutic use</subject><subject>Sexually Transmitted Diseases</subject><subject>Sodium nitroferricyanide</subject><subject>Technetium</subject><subject>Tumors</subject><subject>Ulcers</subject><subject>Vasodilator Agents - therapeutic use</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN0kFv0zAUB_AIgUYZnLmAFCGEdiCbHSeOfRwFyqRCDwyulmM_B1eJ3cWJtH37uWrUMVShygdL_v9sWe-9JHmN0TnGOb0IyoJTcM4wyhFGT5IZRrzMeI7I02SGEKEZQ1X5PHkRwhqhmHFykpxMfJacfYdBtuncdxs_Oh1S69LrP9DLzV0qnU4_W9k4H2x4mTwzsg3watpPk19fv1zPv2XL1eJqfrnMVEXokMmiKjXTRtGqVLnGlCNQstKFVjkxmrGc18pAWasaoFaKKW6KkjBKGOSaG3KafNi9u-n9zQhhEJ0NCtpWOvBjEFXJqhIXPMJ3_8C1H3sX_yZyTEpKOKcPqJEtCOuMH3qpti-KS1yUjGCGI_p4ADXgYhla78DYePw3zw7wuDR0Vh3yZ498JAPcDo0cQxBXP38cTVe_j6afFsdStlj-pxQTVb5toQEROz1fPeIXO656H0IPRmx628n-TmAktvMppvkU08DFG2-nro11B3rvH_L3Uy6Dkq3ppVM27FnBKszptvlvdmwdBt_v4zzOV04ouQcpPfDB</recordid><startdate>19930806</startdate><enddate>19930806</enddate><creator>Abrams, Michael J.</creator><creator>Murrer, Barry A.</creator><general>American Society for the Advancement of Science</general><general>American Association for the Advancement of Science</general><general>The American Association for the Advancement of Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>IBG</scope><scope>IOV</scope><scope>ISN</scope><scope>0-V</scope><scope>3V.</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88B</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8BQ</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CJNVE</scope><scope>D1I</scope><scope>DWQXO</scope><scope>F28</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9-</scope><scope>K9.</scope><scope>KB.</scope><scope>KR7</scope><scope>L6V</scope><scope>L7M</scope><scope>LK8</scope><scope>L~C</scope><scope>L~D</scope><scope>M0K</scope><scope>M0P</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEDU</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>R05</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19930806</creationdate><title>Metal Compounds in Therapy and Diagnosis</title><author>Abrams, Michael J. ; 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| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1993-08, Vol.261 (5122), p.725-730 |
| issn | 0036-8075 1095-9203 |
| language | eng |
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| source | MEDLINE; American Association for the Advancement of Science; Jstor Complete Legacy |
| subjects | Anti-Ulcer Agents - therapeutic use Antineoplastic Agents - therapeutic use Antirheumatic Agents - therapeutic use Arthritis Arthritis - drug therapy Bioinorganic Chemistry Biological and medical sciences Bismuth Bones Cancer Chemotherapy Citrates Contrast media Diagnostic Imaging Drug therapy Gallium Gallium compounds Gold compounds Health aspects Health care Humans Hypercalcemia Hypercalcemia - drug therapy Hypertension Imaging Materials Medical sciences Medical treatment Metal compounds Metal ions Metals Miscellaneous Narcotics Nitric Oxide - metabolism Nitroprusside Nitroprusside - metabolism Nitroprusside - therapeutic use NMR Nuclear magnetic resonance Organic Chemistry Organogold Compounds Organometallic Compounds - therapeutic use Oxides Patients Pharmacology. Drug treatments Physical Characteristics Platinum Platinum compounds Radioisotopes - therapeutic use Sexually Transmitted Diseases Sodium nitroferricyanide Technetium Tumors Ulcers Vasodilator Agents - therapeutic use |
| title | Metal Compounds in Therapy and Diagnosis |
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