Metal Compounds in Therapy and Diagnosis

There is increasing interest in the use of metal-containing compounds in medicine. This review describes several therapeutic applications, such as the use of platinum complexes in cancer chemotherapy, gold compounds in the treatment of arthritis, gallium in hypercalcemia, bismuth in anti-ulcer medic...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1993-08, Vol.261 (5122), p.725-730
Hauptverfasser:	Abrams, Michael J., Murrer, Barry A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Ulcer Agents - therapeutic use Antineoplastic Agents - therapeutic use Antirheumatic Agents - therapeutic use Arthritis Arthritis - drug therapy Bioinorganic Chemistry Biological and medical sciences Bismuth Bones Cancer Chemotherapy Citrates Contrast media Diagnostic Imaging Drug therapy Gallium Gallium compounds Gold compounds Health aspects Health care Humans Hypercalcemia Hypercalcemia - drug therapy Hypertension Imaging Materials Medical sciences Medical treatment Metal compounds Metal ions Metals Miscellaneous Narcotics Nitric Oxide - metabolism Nitroprusside Nitroprusside - metabolism Nitroprusside - therapeutic use NMR Nuclear magnetic resonance Organic Chemistry Organogold Compounds Organometallic Compounds - therapeutic use Oxides Patients Pharmacology. Drug treatments Physical Characteristics Platinum Platinum compounds Radioisotopes - therapeutic use Sexually Transmitted Diseases Sodium nitroferricyanide Technetium Tumors Ulcers Vasodilator Agents - therapeutic use
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Beschreibung
Zusammenfassung:	There is increasing interest in the use of metal-containing compounds in medicine. This review describes several therapeutic applications, such as the use of platinum complexes in cancer chemotherapy, gold compounds in the treatment of arthritis, gallium in hypercalcemia, bismuth in anti-ulcer medication, and sodium nitroprusside in hypertension. The use of metal radionuclides in diagnosis and radiotherapy and the role of paramagnetic metal complexes as contrast agents in magnetic resonance imaging are also discussed.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.8102010