Serum apolipoprotein C-II and apolipoprotein E levels and their lipoprotein distributions in chronic hemodialysis

To investigate the mechanism of hypertriglyceridemia in uremic state, we have determined apoliporotein (apo) C-II and apo E in both serum and lipoproteins in sex or age matched 15 normal controls and in 15 patients on maintenance hemodialysis. Consequently, the following results were summarised. 1) Hypertriglyceridemia was found in the uremic patients while their serum total cholesterol levels remained within normal range. 2) There was a significant positive relationship between serum apo C-II and apo E levels in both normal controls and patients on maintenance hemodialysis. 3) Serum apo C-II levels did not show the significant change between two groups, while serum apo E levels tended to be be low in the patient group. 4) In only uremics, serum triglyceride levels showed a significant positive correlation to serum apo C-II and apo E levels. 5) In the percent distribution of apo C-II in lipoproteins, the patient group had a significant increase in high density lipoproteins and a significant decrease in very low density lipoproteins when compared to those of the control group. Similar alteration in terms of apo E distribution in lipoproteins was observed between two groups accompanied by the additional significant changes such as an increase in low density lipoproteins and a decrease in intermediate density lipoproteins in the natient grnup