Seasonality and period-doubling bifurcations in an epidemic model

The annual incidence rates of some endemic infectious diseases are steady while others fluctuate dramatically, often in a regular cycle. In order to investigate the role of seasonality in driving cycles of recurrent epidemics, we analyze numerically the susceptible/exposed/infective/recovered (SEIR) epidemic model with seasonal transmission. We show that small-amplitude periodic solutions exhibit a sequence of period-doubling bifurcations as the amplitude of seasonal variation increases, predicting a transition to chaos of the kind studied in other biological contexts. The epidemiological implication is that the seasonal mechanism generating biennial epidemics may not be able to account for small-amplitude recurrent epidemics of arbitrary periodicity.