Studies on Hypolipidemic Agents. I. 3-Benzoylglycidic Acid Derivatives
3-Benzoylglycidic acid derivatives were prepared and tested for hypolipidemic properties in normal rats. A structure-activity relationship study showed that trans-3-(phenoxybenzoyl)-glycidic acids have hypolipidemic activity. Among these compounds, trans-3-[4-(4-chlorophenoxy) benzoyl] glycidic acid...
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| Veröffentlicht in: | Chemical & pharmaceutical bulletin 1984/08/25, Vol.32(8), pp.3066-3074 |
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| container_end_page | 3074 |
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| container_issue | 8 |
| container_start_page | 3066 |
| container_title | Chemical & pharmaceutical bulletin |
| container_volume | 32 |
| creator | TOMISAWA, KAZUYUKI KAMEO, KAZUYA GOI, MASAMI SOTA, KAORU |
| description | 3-Benzoylglycidic acid derivatives were prepared and tested for hypolipidemic properties in normal rats. A structure-activity relationship study showed that trans-3-(phenoxybenzoyl)-glycidic acids have hypolipidemic activity. Among these compounds, trans-3-[4-(4-chlorophenoxy) benzoyl] glycidic acid (38) and trans-3-[4-(4-bromophenoxy) benzoyl] glycidic acid (39) possessed very potent activities. |
| doi_str_mv | 10.1248/cpb.32.3066 |
| format | Article |
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I. 3-Benzoylglycidic Acid Derivatives</atitle><jtitle>Chemical & pharmaceutical bulletin</jtitle><addtitle>Chem. Pharm. Bull.</addtitle><date>1984</date><risdate>1984</risdate><volume>32</volume><issue>8</issue><spage>3066</spage><epage>3074</epage><pages>3066-3074</pages><issn>0009-2363</issn><eissn>1347-5223</eissn><coden>CPBTAL</coden><abstract>3-Benzoylglycidic acid derivatives were prepared and tested for hypolipidemic properties in normal rats. A structure-activity relationship study showed that trans-3-(phenoxybenzoyl)-glycidic acids have hypolipidemic activity. Among these compounds, trans-3-[4-(4-chlorophenoxy) benzoyl] glycidic acid (38) and trans-3-[4-(4-bromophenoxy) benzoyl] glycidic acid (39) possessed very potent activities.</abstract><cop>Tokyo</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>6518588</pmid><doi>10.1248/cpb.32.3066</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0009-2363 |
| ispartof | Chemical and Pharmaceutical Bulletin, 1984/08/25, Vol.32(8), pp.3066-3074 |
| issn | 0009-2363 1347-5223 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75849340 |
| source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Animals Benzoates - chemical synthesis Chemical Phenomena Chemistry clofibrate Epoxy Compounds - chemical synthesis Ethers, Cyclic - chemical synthesis Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with o, s, se, te hetero atom and condensed derivatives Hypolipidemic Agents - chemical synthesis Male Organic chemistry Preparations and properties Propionates - chemical synthesis Rats Structure-Activity Relationship |
| title | Studies on Hypolipidemic Agents. I. 3-Benzoylglycidic Acid Derivatives |
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