Studies on Hypolipidemic Agents. I. 3-Benzoylglycidic Acid Derivatives

3-Benzoylglycidic acid derivatives were prepared and tested for hypolipidemic properties in normal rats. A structure-activity relationship study showed that trans-3-(phenoxybenzoyl)-glycidic acids have hypolipidemic activity. Among these compounds, trans-3-[4-(4-chlorophenoxy) benzoyl] glycidic acid...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1984/08/25, Vol.32(8), pp.3066-3074
Hauptverfasser:	TOMISAWA, KAZUYUKI, KAMEO, KAZUYA, GOI, MASAMI, SOTA, KAORU
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzoates - chemical synthesis Chemical Phenomena Chemistry clofibrate Epoxy Compounds - chemical synthesis Ethers, Cyclic - chemical synthesis Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with o, s, se, te hetero atom and condensed derivatives Hypolipidemic Agents - chemical synthesis Male Organic chemistry Preparations and properties Propionates - chemical synthesis Rats Structure-Activity Relationship
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Beschreibung
Zusammenfassung:	3-Benzoylglycidic acid derivatives were prepared and tested for hypolipidemic properties in normal rats. A structure-activity relationship study showed that trans-3-(phenoxybenzoyl)-glycidic acids have hypolipidemic activity. Among these compounds, trans-3-[4-(4-chlorophenoxy) benzoyl] glycidic acid (38) and trans-3-[4-(4-bromophenoxy) benzoyl] glycidic acid (39) possessed very potent activities.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.32.3066