Conioidines A and B, Novel DNA-interacting Pyrrolidines from Chamaesaracha conioides

Two novel pyrrolidine compounds, conioidines A [1] and B [2], have been isolated from the Texas plant, Chamaesaracha conioides (Solanaceae). Their structures were determined by spectroscopic methods and hydrolysis studies. Both natural products, like doxorubicin, showed DNA-specific KB cell cytotoxi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 1993-05, Vol.56 (5), p.708-713
Hauptverfasser:	Chan, George W, Berry, David, DeBrosse, Charles W, Houling, Mark E, MacKenzie-LoCasto, Laurie, Offen, Priscilla H, Westley, John W
Format:	Artikel
Sprache:	eng
Schlagworte:	ADN AGENTES ANTINEOPLASTICOS ALCALOIDE ALCALOIDES ALKALOIDS Animals ANTIMICROBIAL PROPERTIES ANTINEOPLASTIC AGENTS Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - pharmacology Cattle Cell Survival - drug effects DNA DNA, Neoplasm - drug effects Doxorubicin - pharmacology EXTRACTOS VEGETALES EXTRAIT D'ORIGINE VEGETALE Humans Hydrolysis KB Cells MEDICAMENT CYTOSTATIQUE molecular structure PLANT EXTRACTS Plants, Medicinal - chemistry PROPIEDADES ANTIMICROBIANAS PROPRIETE ANTIMICROBIENNE PYRROLIDINE ALKALOIDS Pyrrolidines - chemistry Pyrrolidines - pharmacology SOLANACEAE Solanaceous Alkaloids - chemistry Solanaceous Alkaloids - pharmacology STRUCTURE TEXAS
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Two novel pyrrolidine compounds, conioidines A [1] and B [2], have been isolated from the Texas plant, Chamaesaracha conioides (Solanaceae). Their structures were determined by spectroscopic methods and hydrolysis studies. Both natural products, like doxorubicin, showed DNA-specific KB cell cytotoxicity. Dose-response data indicated a Kd value of 2.8 microM for binding of conioidine A [1] to calf thymus DNA.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np50095a007