The cortico-nigral projection: reduced glutamate content in the substantia nigra following frontal cortex ablation in the rat
Unilateral ablation of the frontal cortex results in a significant reduction (19.5%) of glutamic acid in the ipsilateral compared with the contralateral substantia nigra. The GABA level in the substantia nigra and both the glutamate and GABA levels in the hippocampus remain unchanged. The results su...
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| Veröffentlicht in: | Brain research 1984-11, Vol.322 (1), p.124-126 |
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| container_title | Brain research |
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| creator | Kornhuber, Johannes Kim, Jin-Soo Kornhuber, Malte E. Kornhuber, Hans H. |
| description | Unilateral ablation of the frontal cortex results in a significant reduction (19.5%) of glutamic acid in the ipsilateral compared with the contralateral substantia nigra. The GABA level in the substantia nigra and both the glutamate and GABA levels in the hippocampus remain unchanged. The results suggest that glutamate is a transmitter in the cortico-nigral fibre tract. |
| doi_str_mv | 10.1016/0006-8993(84)91189-2 |
| format | Article |
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The GABA level in the substantia nigra and both the glutamate and GABA levels in the hippocampus remain unchanged. The results suggest that glutamate is a transmitter in the cortico-nigral fibre tract.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(84)91189-2</identifier><identifier>PMID: 6151416</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Animals ; Biological and medical sciences ; Central nervous system ; Central neurotransmission. Neuromudulation. Pathways and receptors ; cerebral cortex ; Efferent Pathways - anatomy & histology ; Frontal Lobe - anatomy & histology ; Frontal Lobe - physiology ; Fundamental and applied biological sciences. Psychology ; glutamate ; Glutamates - analysis ; Glutamates - physiology ; Glutamic Acid ; Hippocampus - analysis ; Male ; neurotransmitters ; Rats ; substantia nigra ; Substantia Nigra - analysis ; Substantia Nigra - anatomy & histology ; Substantia Nigra - physiology ; Synaptic Transmission ; Vertebrates: nervous system and sense organs</subject><ispartof>Brain research, 1984-11, Vol.322 (1), p.124-126</ispartof><rights>1984 Elsevier Science Publishers B.V., Amsterdam</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-6bff757c39471c8ba649c9720613ade330107f92fdeddc4f8f9fc8ee3ca450f13</citedby><cites>FETCH-LOGICAL-c417t-6bff757c39471c8ba649c9720613ade330107f92fdeddc4f8f9fc8ee3ca450f13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0006899384911892$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65308</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8957387$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6151416$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kornhuber, Johannes</creatorcontrib><creatorcontrib>Kim, Jin-Soo</creatorcontrib><creatorcontrib>Kornhuber, Malte E.</creatorcontrib><creatorcontrib>Kornhuber, Hans H.</creatorcontrib><title>The cortico-nigral projection: reduced glutamate content in the substantia nigra following frontal cortex ablation in the rat</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>Unilateral ablation of the frontal cortex results in a significant reduction (19.5%) of glutamic acid in the ipsilateral compared with the contralateral substantia nigra. The GABA level in the substantia nigra and both the glutamate and GABA levels in the hippocampus remain unchanged. The results suggest that glutamate is a transmitter in the cortico-nigral fibre tract.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Central nervous system</subject><subject>Central neurotransmission. Neuromudulation. Pathways and receptors</subject><subject>cerebral cortex</subject><subject>Efferent Pathways - anatomy & histology</subject><subject>Frontal Lobe - anatomy & histology</subject><subject>Frontal Lobe - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>glutamate</subject><subject>Glutamates - analysis</subject><subject>Glutamates - physiology</subject><subject>Glutamic Acid</subject><subject>Hippocampus - analysis</subject><subject>Male</subject><subject>neurotransmitters</subject><subject>Rats</subject><subject>substantia nigra</subject><subject>Substantia Nigra - analysis</subject><subject>Substantia Nigra - anatomy & histology</subject><subject>Substantia Nigra - physiology</subject><subject>Synaptic Transmission</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFvFSEUhYnR1Gf1H2jCwhhdjMLADODCxDTVmjRxU9eEYS5PGh5UYKwu_O8yfc-3rKsbcr9zcjkHoeeUvKWEju8IIWMnlWKvJX-jKJWq6x-gDZWi78aek4doc0QeoyelXLcnY4qcoJORDpTTcYP-XH0HbFOu3qYu-m02Ad_kdA22-hTf4wzzYmHG27BUszN1hWOFWLGPuDZtWaZSTaze4Ds5dimEdOvjFrvc0Oa32sMvbKZgVtN_ymzqU_TImVDg2WGeom-fzq_OLrrLr5-_nH287Cynonbj5JwYhGWKC2rlZEaurBI9GSkzMzBGKBFO9W6GebbcSaeclQDMGj4QR9kperX3bV_7sUCpeueLhRBMhLQULQbJGefkvyDlhA9qkA3ke9DmVEoGp2-y35n8W1Oi13r0mr1es9eS67t6dN9kLw7-y7SD-Sg69NH2Lw97U6wJLptofTliUg2CSdGwD3sMWmg_PWRdrIfYivK5Nafn5O-_4y-bta4g</recordid><startdate>19841119</startdate><enddate>19841119</enddate><creator>Kornhuber, Johannes</creator><creator>Kim, Jin-Soo</creator><creator>Kornhuber, Malte E.</creator><creator>Kornhuber, Hans H.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19841119</creationdate><title>The cortico-nigral projection: reduced glutamate content in the substantia nigra following frontal cortex ablation in the rat</title><author>Kornhuber, Johannes ; Kim, Jin-Soo ; Kornhuber, Malte E. ; Kornhuber, Hans H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-6bff757c39471c8ba649c9720613ade330107f92fdeddc4f8f9fc8ee3ca450f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Central nervous system</topic><topic>Central neurotransmission. Neuromudulation. Pathways and receptors</topic><topic>cerebral cortex</topic><topic>Efferent Pathways - anatomy & histology</topic><topic>Frontal Lobe - anatomy & histology</topic><topic>Frontal Lobe - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>glutamate</topic><topic>Glutamates - analysis</topic><topic>Glutamates - physiology</topic><topic>Glutamic Acid</topic><topic>Hippocampus - analysis</topic><topic>Male</topic><topic>neurotransmitters</topic><topic>Rats</topic><topic>substantia nigra</topic><topic>Substantia Nigra - analysis</topic><topic>Substantia Nigra - anatomy & histology</topic><topic>Substantia Nigra - physiology</topic><topic>Synaptic Transmission</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kornhuber, Johannes</creatorcontrib><creatorcontrib>Kim, Jin-Soo</creatorcontrib><creatorcontrib>Kornhuber, Malte E.</creatorcontrib><creatorcontrib>Kornhuber, Hans H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kornhuber, Johannes</au><au>Kim, Jin-Soo</au><au>Kornhuber, Malte E.</au><au>Kornhuber, Hans H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The cortico-nigral projection: reduced glutamate content in the substantia nigra following frontal cortex ablation in the rat</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1984-11-19</date><risdate>1984</risdate><volume>322</volume><issue>1</issue><spage>124</spage><epage>126</epage><pages>124-126</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>Unilateral ablation of the frontal cortex results in a significant reduction (19.5%) of glutamic acid in the ipsilateral compared with the contralateral substantia nigra. The GABA level in the substantia nigra and both the glutamate and GABA levels in the hippocampus remain unchanged. The results suggest that glutamate is a transmitter in the cortico-nigral fibre tract.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>6151416</pmid><doi>10.1016/0006-8993(84)91189-2</doi><tpages>3</tpages></addata></record> |
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| ispartof | Brain research, 1984-11, Vol.322 (1), p.124-126 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Biological and medical sciences Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors cerebral cortex Efferent Pathways - anatomy & histology Frontal Lobe - anatomy & histology Frontal Lobe - physiology Fundamental and applied biological sciences. Psychology glutamate Glutamates - analysis Glutamates - physiology Glutamic Acid Hippocampus - analysis Male neurotransmitters Rats substantia nigra Substantia Nigra - analysis Substantia Nigra - anatomy & histology Substantia Nigra - physiology Synaptic Transmission Vertebrates: nervous system and sense organs |
| title | The cortico-nigral projection: reduced glutamate content in the substantia nigra following frontal cortex ablation in the rat |
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