The cortico-nigral projection: reduced glutamate content in the substantia nigra following frontal cortex ablation in the rat

Unilateral ablation of the frontal cortex results in a significant reduction (19.5%) of glutamic acid in the ipsilateral compared with the contralateral substantia nigra. The GABA level in the substantia nigra and both the glutamate and GABA levels in the hippocampus remain unchanged. The results su...

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Veröffentlicht in:	Brain research 1984-11, Vol.322 (1), p.124-126
Hauptverfasser:	Kornhuber, Johannes, Kim, Jin-Soo, Kornhuber, Malte E., Kornhuber, Hans H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors cerebral cortex Efferent Pathways - anatomy & histology Frontal Lobe - anatomy & histology Frontal Lobe - physiology Fundamental and applied biological sciences. Psychology glutamate Glutamates - analysis Glutamates - physiology Glutamic Acid Hippocampus - analysis Male neurotransmitters Rats substantia nigra Substantia Nigra - analysis Substantia Nigra - anatomy & histology Substantia Nigra - physiology Synaptic Transmission Vertebrates: nervous system and sense organs
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Zusammenfassung:	Unilateral ablation of the frontal cortex results in a significant reduction (19.5%) of glutamic acid in the ipsilateral compared with the contralateral substantia nigra. The GABA level in the substantia nigra and both the glutamate and GABA levels in the hippocampus remain unchanged. The results suggest that glutamate is a transmitter in the cortico-nigral fibre tract.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/0006-8993(84)91189-2