Tyr-MIF-1 acts as an opiate antagonist in the tail-flick test

The naturally occurring brain peptide Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH 2) was tested for its ability to block and reverse the actions of morphine in the tail-flick test. Injected peripherally either 10 minutes before or after morphine, Tyr-MIF-1, like MIF-1, was found to significantly reduce the antino...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 1984-12, Vol.21 (6), p.937-941
Hauptverfasser:	Kastin, Abba J., Stephens, Elizabeth, Ehrensing, Rudolph H., Fischman, Alan J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesia Analgesics Animals Biological and medical sciences Brain Hot Temperature - adverse effects Male Medical sciences Mice Mice, Inbred ICR Morphine Morphine - antagonists & inhibitors MSH Release-Inhibiting Hormone - analogs & derivatives MSH Release-Inhibiting Hormone - pharmacology Naloxone Naloxone - pharmacology Narcotic Antagonists Neuropharmacology Pain - drug therapy Peptide Pharmacology. Drug treatments
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Beschreibung
Zusammenfassung:	The naturally occurring brain peptide Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH 2) was tested for its ability to block and reverse the actions of morphine in the tail-flick test. Injected peripherally either 10 minutes before or after morphine, Tyr-MIF-1, like MIF-1, was found to significantly reduce the antinociceptive actions of morphine on thermal pain. The results indicate that Tyr-MIF-i may act, in part, as an endogenous opiate antagonist.
ISSN:	0091-3057 1873-5177
DOI:	10.1016/S0091-3057(84)80076-3