Effect of human granulocyte colony stimulating factor on neuroblastoma cell growth

We have studied the effect of recombinant human granulocyte colony-stimulating factor (G-CSF) on the growth of three different human neuroblastoma (NB) cell lines. using a clonal cell culture and a short proliferation test. The results have shown a lack of effect of G-CSF on the three cell lines. These data promote the use, in clinical trials, of G-CSF as adjunctive treatment in children with NB receiving intensive chemotherapy. L'action du G-CSF ( Granulocyte Colony Stimulating Factor) .cur lei croisscutce de lignees cellulaires de neuroblastomes (NB), a été etudiée à l'aide de tests clonogenigues et de prolfli%ration cellulaire. Le.s resultats tnontrent tine absence d'effet stimulant .sur trois lignees et permettent donc d'envisager ('utilisation du G-CSF daps de.s essais cliniyues chez des er((ants atteints de NB et recevant line chimiothérapie aplasianle.