C-peptide, insulin-like growth factors I and II, and insulin-like growth factor binding protein-1 in umbilical cord serum: Correlations with birth weight
Objective: Our purpose was to determine the correlation between birth weight and hormones or growth factors believed to be involved in fetal growth: insulin, insulin-like growth factors I and II, and insulin-like growth factor binding protein-1. Study Design: Five hundred thirty-eight cord serum sam...
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| Veröffentlicht in: | American journal of obstetrics and gynecology 1993-07, Vol.169 (1), p.89-97 |
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| container_title | American journal of obstetrics and gynecology |
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| creator | Verhaeghe, Johan Van Bree, Rita Van Herck, Erik Laureys, Jozef Bouillon, Roger Van Assche, F. André |
| description | Objective: Our purpose was to determine the correlation between birth weight and hormones or growth factors believed to be involved in fetal growth: insulin, insulin-like growth factors I and II, and insulin-like growth factor binding protein-1.
Study Design: Five hundred thirty-eight cord serum samples were analyzed for insulin-like growth factor-l, insulin-like growth factor-ll, C-peptide, and insulin-like growth factor binding protein-1 by immunoassay. Samples included all gestational ages in the third trimester and a large range of birth weights.
Results: Cord serum insulin-like growth factor-l concentrations increased until 39 weeks (+84% from 28 to 29 weeks), followed by a 21% decline at 41 weeks. Insulin-like growth factor-I levels were decreased by 40% in small-for-gestational-age (< 10th percentile) newborns and were increased by 28% in large-for-gestational-age (>90th percentile) newborns in the absence of diabetes. Insulin-like growth factor-I levels were best correlated with birth weight (
R = 0.48,
p < 0.001). Cord serum insulin-like growth factor-II concentrations were sixfold to tenfold higher than those of insulin-like growth factor-I and were 8% to 10% (
p < 0.001) higher in large-for-gestational-age than in average-weight and small-for-gestational-age newborns. Cord serum C-peptide concentrations were 28% and 34% higher in large-for-gestational-age than in average-for-gestational-age and small-for-gestational-age newborns, respectively. Insulin-like growth factor binding protein-1 levels were increased in preterm average-for-gestational-age and in term small-for-gestational-age newborns compared with term average-for-gestational-age newborns and showed a negative correlation with birth weight (
R = − 0.43,
n = 131,
p < 0.001). Insulin-like growth factor binding protein-1 was not correlated with C-peptide concentrations.
Conclusions: Insulin-like growth factors I and II and insulin are all related to fetal growth and weight gain, and insulin-like growth factor-l correlates best with birth weight. Insulin is mainly related to fetal overgrowth (macrosomia). Insulin-like growth factor binding protein-1 may be a growth inhibitor in the fetus. |
| doi_str_mv | 10.1016/0002-9378(93)90137-8 |
| format | Article |
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Study Design: Five hundred thirty-eight cord serum samples were analyzed for insulin-like growth factor-l, insulin-like growth factor-ll, C-peptide, and insulin-like growth factor binding protein-1 by immunoassay. Samples included all gestational ages in the third trimester and a large range of birth weights.
Results: Cord serum insulin-like growth factor-l concentrations increased until 39 weeks (+84% from 28 to 29 weeks), followed by a 21% decline at 41 weeks. Insulin-like growth factor-I levels were decreased by 40% in small-for-gestational-age (< 10th percentile) newborns and were increased by 28% in large-for-gestational-age (>90th percentile) newborns in the absence of diabetes. Insulin-like growth factor-I levels were best correlated with birth weight (
R = 0.48,
p < 0.001). Cord serum insulin-like growth factor-II concentrations were sixfold to tenfold higher than those of insulin-like growth factor-I and were 8% to 10% (
p < 0.001) higher in large-for-gestational-age than in average-weight and small-for-gestational-age newborns. Cord serum C-peptide concentrations were 28% and 34% higher in large-for-gestational-age than in average-for-gestational-age and small-for-gestational-age newborns, respectively. Insulin-like growth factor binding protein-1 levels were increased in preterm average-for-gestational-age and in term small-for-gestational-age newborns compared with term average-for-gestational-age newborns and showed a negative correlation with birth weight (
R = − 0.43,
n = 131,
p < 0.001). Insulin-like growth factor binding protein-1 was not correlated with C-peptide concentrations.
Conclusions: Insulin-like growth factors I and II and insulin are all related to fetal growth and weight gain, and insulin-like growth factor-l correlates best with birth weight. Insulin is mainly related to fetal overgrowth (macrosomia). Insulin-like growth factor binding protein-1 may be a growth inhibitor in the fetus.</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1016/0002-9378(93)90137-8</identifier><identifier>PMID: 7687409</identifier><identifier>CODEN: AJOGAH</identifier><language>eng</language><publisher>Philadelphia, PA: Mosby, Inc</publisher><subject>Adult ; Biological and medical sciences ; Birth Weight ; C-peptide ; C-Peptide - blood ; Carrier Proteins - blood ; Delivery. Postpartum. Lactation ; Female ; Fetal Blood - metabolism ; Gynecology. Andrology. Obstetrics ; Humans ; Infant, Newborn ; Infant, Small for Gestational Age - blood ; Insulin-Like Growth Factor Binding Protein 1 ; Insulin-Like Growth Factor I - metabolism ; Insulin-Like Growth Factor II - metabolism ; insulin-like growth factor-I ; insulin-like growth factor-II ; Male ; Maternal, fetal and perinatal monitoring ; Medical sciences</subject><ispartof>American journal of obstetrics and gynecology, 1993-07, Vol.169 (1), p.89-97</ispartof><rights>1993 Mosby</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c301t-111facf3d82f0117d8fd058096b11bc886a6d6d519f67b7da9f6f9ccf9b41bd83</citedby><cites>FETCH-LOGICAL-c301t-111facf3d82f0117d8fd058096b11bc886a6d6d519f67b7da9f6f9ccf9b41bd83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0002-9378(93)90137-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4906930$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7687409$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Verhaeghe, Johan</creatorcontrib><creatorcontrib>Van Bree, Rita</creatorcontrib><creatorcontrib>Van Herck, Erik</creatorcontrib><creatorcontrib>Laureys, Jozef</creatorcontrib><creatorcontrib>Bouillon, Roger</creatorcontrib><creatorcontrib>Van Assche, F. André</creatorcontrib><title>C-peptide, insulin-like growth factors I and II, and insulin-like growth factor binding protein-1 in umbilical cord serum: Correlations with birth weight</title><title>American journal of obstetrics and gynecology</title><addtitle>Am J Obstet Gynecol</addtitle><description>Objective: Our purpose was to determine the correlation between birth weight and hormones or growth factors believed to be involved in fetal growth: insulin, insulin-like growth factors I and II, and insulin-like growth factor binding protein-1.
Study Design: Five hundred thirty-eight cord serum samples were analyzed for insulin-like growth factor-l, insulin-like growth factor-ll, C-peptide, and insulin-like growth factor binding protein-1 by immunoassay. Samples included all gestational ages in the third trimester and a large range of birth weights.
Results: Cord serum insulin-like growth factor-l concentrations increased until 39 weeks (+84% from 28 to 29 weeks), followed by a 21% decline at 41 weeks. Insulin-like growth factor-I levels were decreased by 40% in small-for-gestational-age (< 10th percentile) newborns and were increased by 28% in large-for-gestational-age (>90th percentile) newborns in the absence of diabetes. Insulin-like growth factor-I levels were best correlated with birth weight (
R = 0.48,
p < 0.001). Cord serum insulin-like growth factor-II concentrations were sixfold to tenfold higher than those of insulin-like growth factor-I and were 8% to 10% (
p < 0.001) higher in large-for-gestational-age than in average-weight and small-for-gestational-age newborns. Cord serum C-peptide concentrations were 28% and 34% higher in large-for-gestational-age than in average-for-gestational-age and small-for-gestational-age newborns, respectively. Insulin-like growth factor binding protein-1 levels were increased in preterm average-for-gestational-age and in term small-for-gestational-age newborns compared with term average-for-gestational-age newborns and showed a negative correlation with birth weight (
R = − 0.43,
n = 131,
p < 0.001). Insulin-like growth factor binding protein-1 was not correlated with C-peptide concentrations.
Conclusions: Insulin-like growth factors I and II and insulin are all related to fetal growth and weight gain, and insulin-like growth factor-l correlates best with birth weight. Insulin is mainly related to fetal overgrowth (macrosomia). Insulin-like growth factor binding protein-1 may be a growth inhibitor in the fetus.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Birth Weight</subject><subject>C-peptide</subject><subject>C-Peptide - blood</subject><subject>Carrier Proteins - blood</subject><subject>Delivery. Postpartum. Lactation</subject><subject>Female</subject><subject>Fetal Blood - metabolism</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Infant, Small for Gestational Age - blood</subject><subject>Insulin-Like Growth Factor Binding Protein 1</subject><subject>Insulin-Like Growth Factor I - metabolism</subject><subject>Insulin-Like Growth Factor II - metabolism</subject><subject>insulin-like growth factor-I</subject><subject>insulin-like growth factor-II</subject><subject>Male</subject><subject>Maternal, fetal and perinatal monitoring</subject><subject>Medical sciences</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc9uEzEQxi0EKmnhDUDyAaEidcHObrw2ByQUURqpEhc4W_6bDuzawfYS8Si8Ld4myq29zCdrfjMefR9Cryh5TwllHwghy0a0Pb8U7TtBaNs3_AlaUCL6hnHGn6LFCXmOznP-OT-XYnmGznrG-46IBfq3bnZuV8C6KwwhTwOEZoBfDm9T3Jc77JUpMWW8wSpYvNlc3evDJNYQLIQt3qVYXEVohfE0ahjAqAGbmCzOLk3jR7yOKblBFYgh4z3UHRpSrXsH27vyAj3zasju5VEv0I_rL9_XN83tt6-b9efbxrSEloZSWn_2reVLTyjtLfeWrDgRTFOqDedMMcvsigrPet1bVdULY7zQHdWWtxfo7WFvvfj35HKRI2TjhkEFF6cs-xXvaLuawe4AmhRzTs7LXYJRpb-SEjknImd_5Wx3LfI-ETmPvT7un_To7GnoGEHtvzn2Va4O-aSCgXzCOkGYaEnFPh0wV734Ay7JbMAF4ywkZ4q0ER6_4z9Cc6mS</recordid><startdate>199307</startdate><enddate>199307</enddate><creator>Verhaeghe, Johan</creator><creator>Van Bree, Rita</creator><creator>Van Herck, Erik</creator><creator>Laureys, Jozef</creator><creator>Bouillon, Roger</creator><creator>Van Assche, F. André</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199307</creationdate><title>C-peptide, insulin-like growth factors I and II, and insulin-like growth factor binding protein-1 in umbilical cord serum: Correlations with birth weight</title><author>Verhaeghe, Johan ; Van Bree, Rita ; Van Herck, Erik ; Laureys, Jozef ; Bouillon, Roger ; Van Assche, F. André</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c301t-111facf3d82f0117d8fd058096b11bc886a6d6d519f67b7da9f6f9ccf9b41bd83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Birth Weight</topic><topic>C-peptide</topic><topic>C-Peptide - blood</topic><topic>Carrier Proteins - blood</topic><topic>Delivery. Postpartum. Lactation</topic><topic>Female</topic><topic>Fetal Blood - metabolism</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Infant, Small for Gestational Age - blood</topic><topic>Insulin-Like Growth Factor Binding Protein 1</topic><topic>Insulin-Like Growth Factor I - metabolism</topic><topic>Insulin-Like Growth Factor II - metabolism</topic><topic>insulin-like growth factor-I</topic><topic>insulin-like growth factor-II</topic><topic>Male</topic><topic>Maternal, fetal and perinatal monitoring</topic><topic>Medical sciences</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Verhaeghe, Johan</creatorcontrib><creatorcontrib>Van Bree, Rita</creatorcontrib><creatorcontrib>Van Herck, Erik</creatorcontrib><creatorcontrib>Laureys, Jozef</creatorcontrib><creatorcontrib>Bouillon, Roger</creatorcontrib><creatorcontrib>Van Assche, F. André</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Verhaeghe, Johan</au><au>Van Bree, Rita</au><au>Van Herck, Erik</au><au>Laureys, Jozef</au><au>Bouillon, Roger</au><au>Van Assche, F. André</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>C-peptide, insulin-like growth factors I and II, and insulin-like growth factor binding protein-1 in umbilical cord serum: Correlations with birth weight</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>1993-07</date><risdate>1993</risdate><volume>169</volume><issue>1</issue><spage>89</spage><epage>97</epage><pages>89-97</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><coden>AJOGAH</coden><abstract>Objective: Our purpose was to determine the correlation between birth weight and hormones or growth factors believed to be involved in fetal growth: insulin, insulin-like growth factors I and II, and insulin-like growth factor binding protein-1.
Study Design: Five hundred thirty-eight cord serum samples were analyzed for insulin-like growth factor-l, insulin-like growth factor-ll, C-peptide, and insulin-like growth factor binding protein-1 by immunoassay. Samples included all gestational ages in the third trimester and a large range of birth weights.
Results: Cord serum insulin-like growth factor-l concentrations increased until 39 weeks (+84% from 28 to 29 weeks), followed by a 21% decline at 41 weeks. Insulin-like growth factor-I levels were decreased by 40% in small-for-gestational-age (< 10th percentile) newborns and were increased by 28% in large-for-gestational-age (>90th percentile) newborns in the absence of diabetes. Insulin-like growth factor-I levels were best correlated with birth weight (
R = 0.48,
p < 0.001). Cord serum insulin-like growth factor-II concentrations were sixfold to tenfold higher than those of insulin-like growth factor-I and were 8% to 10% (
p < 0.001) higher in large-for-gestational-age than in average-weight and small-for-gestational-age newborns. Cord serum C-peptide concentrations were 28% and 34% higher in large-for-gestational-age than in average-for-gestational-age and small-for-gestational-age newborns, respectively. Insulin-like growth factor binding protein-1 levels were increased in preterm average-for-gestational-age and in term small-for-gestational-age newborns compared with term average-for-gestational-age newborns and showed a negative correlation with birth weight (
R = − 0.43,
n = 131,
p < 0.001). Insulin-like growth factor binding protein-1 was not correlated with C-peptide concentrations.
Conclusions: Insulin-like growth factors I and II and insulin are all related to fetal growth and weight gain, and insulin-like growth factor-l correlates best with birth weight. Insulin is mainly related to fetal overgrowth (macrosomia). Insulin-like growth factor binding protein-1 may be a growth inhibitor in the fetus.</abstract><cop>Philadelphia, PA</cop><pub>Mosby, Inc</pub><pmid>7687409</pmid><doi>10.1016/0002-9378(93)90137-8</doi><tpages>9</tpages></addata></record> |
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| ispartof | American journal of obstetrics and gynecology, 1993-07, Vol.169 (1), p.89-97 |
| issn | 0002-9378 1097-6868 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adult Biological and medical sciences Birth Weight C-peptide C-Peptide - blood Carrier Proteins - blood Delivery. Postpartum. Lactation Female Fetal Blood - metabolism Gynecology. Andrology. Obstetrics Humans Infant, Newborn Infant, Small for Gestational Age - blood Insulin-Like Growth Factor Binding Protein 1 Insulin-Like Growth Factor I - metabolism Insulin-Like Growth Factor II - metabolism insulin-like growth factor-I insulin-like growth factor-II Male Maternal, fetal and perinatal monitoring Medical sciences |
| title | C-peptide, insulin-like growth factors I and II, and insulin-like growth factor binding protein-1 in umbilical cord serum: Correlations with birth weight |
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