Ion-Pair High-Performance Liquid Chromatographic Analysis of Sulpyrine and Its Metabolites in Rabbit Plasma
A simple, specific and sensitive ion-pair high-performance liquid chromatographic analysis was developed for aminopyrine, sulpyrine and their metabolites (4-methylaminoantipyrine, 4-aminoantipyrine, 4-acetylaminoantipyrine and 4-formylaminoantipyrine) in rabbit plasma. Following deproteinization wit...
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| Veröffentlicht in: | Chemical & pharmaceutical bulletin 1984/08/25, Vol.32(8), pp.3194-3198 |
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| container_title | Chemical & pharmaceutical bulletin |
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| creator | ITOH, SOICHI TANABE, KAZUHISA FURUICHI, YUMI SUZUKA, TAKUMI KUBO, KAZUYOSHI YAMAZAKI, MASARU KAMADA, AKIRA |
| description | A simple, specific and sensitive ion-pair high-performance liquid chromatographic analysis was developed for aminopyrine, sulpyrine and their metabolites (4-methylaminoantipyrine, 4-aminoantipyrine, 4-acetylaminoantipyrine and 4-formylaminoantipyrine) in rabbit plasma. Following deproteinization with acetonitrile and separation on an octadecylsilane-bonded silica column (250×4mm, JASCO Fine SIL C-18), the eluted components were detected with a multiwavelength ultraviolet monitor at 260nm. The mobile phase consisted of 22% (v/v) acetonitrile and 78% (v/v) of an aqueous solution containing 10mM KH2PO4 and 1.24mM tetra-n-butylammonium bromide, adjusted to pH 4.5 with 0.1M phosphoric acid solution. Hexobarbital was employed as an internal standard. Based on 0.1ml of plasma, the detection limits were 0.35μM for 4-acetylaminoantipyrine, 0.35μM for 4-formylaminoantipyrine, 0.7μM for sulpyrine, 1μM for 4-aminoantipyrine, and 2μM for 4-methylaminoantipyrine at the signal-to-noise ratio of 5 : 1. |
| doi_str_mv | 10.1248/cpb.32.3194 |
| format | Article |
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Following deproteinization with acetonitrile and separation on an octadecylsilane-bonded silica column (250×4mm, JASCO Fine SIL C-18), the eluted components were detected with a multiwavelength ultraviolet monitor at 260nm. The mobile phase consisted of 22% (v/v) acetonitrile and 78% (v/v) of an aqueous solution containing 10mM KH2PO4 and 1.24mM tetra-n-butylammonium bromide, adjusted to pH 4.5 with 0.1M phosphoric acid solution. Hexobarbital was employed as an internal standard. Based on 0.1ml of plasma, the detection limits were 0.35μM for 4-acetylaminoantipyrine, 0.35μM for 4-formylaminoantipyrine, 0.7μM for sulpyrine, 1μM for 4-aminoantipyrine, and 2μM for 4-methylaminoantipyrine at the signal-to-noise ratio of 5 : 1.</description><identifier>ISSN: 0009-2363</identifier><identifier>EISSN: 1347-5223</identifier><identifier>DOI: 10.1248/cpb.32.3194</identifier><identifier>PMID: 6518598</identifier><identifier>CODEN: CPBTAL</identifier><language>eng</language><publisher>Tokyo: The Pharmaceutical Society of Japan</publisher><subject>Aminopyrine - analogs & derivatives ; Aminopyrine - blood ; Analysis ; Animals ; Biological and medical sciences ; Chromatography, High Pressure Liquid - methods ; Dipyrone - blood ; General pharmacology ; Medical sciences ; Pharmacology. Drug treatments ; plasma concentration ; Rabbits</subject><ispartof>Chemical and Pharmaceutical Bulletin, 1984/08/25, Vol.32(8), pp.3194-3198</ispartof><rights>The Pharmaceutical Society of Japan</rights><rights>1985 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 1984</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c635t-927141022ac91d27022278a385f2a5981af634f88be389bdbe39d6ffc175ce583</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9202340$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6518598$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ITOH, SOICHI</creatorcontrib><creatorcontrib>TANABE, KAZUHISA</creatorcontrib><creatorcontrib>FURUICHI, YUMI</creatorcontrib><creatorcontrib>SUZUKA, TAKUMI</creatorcontrib><creatorcontrib>KUBO, KAZUYOSHI</creatorcontrib><creatorcontrib>YAMAZAKI, MASARU</creatorcontrib><creatorcontrib>KAMADA, AKIRA</creatorcontrib><title>Ion-Pair High-Performance Liquid Chromatographic Analysis of Sulpyrine and Its Metabolites in Rabbit Plasma</title><title>Chemical & pharmaceutical bulletin</title><addtitle>Chem. Pharm. Bull.</addtitle><description>A simple, specific and sensitive ion-pair high-performance liquid chromatographic analysis was developed for aminopyrine, sulpyrine and their metabolites (4-methylaminoantipyrine, 4-aminoantipyrine, 4-acetylaminoantipyrine and 4-formylaminoantipyrine) in rabbit plasma. Following deproteinization with acetonitrile and separation on an octadecylsilane-bonded silica column (250×4mm, JASCO Fine SIL C-18), the eluted components were detected with a multiwavelength ultraviolet monitor at 260nm. The mobile phase consisted of 22% (v/v) acetonitrile and 78% (v/v) of an aqueous solution containing 10mM KH2PO4 and 1.24mM tetra-n-butylammonium bromide, adjusted to pH 4.5 with 0.1M phosphoric acid solution. Hexobarbital was employed as an internal standard. Based on 0.1ml of plasma, the detection limits were 0.35μM for 4-acetylaminoantipyrine, 0.35μM for 4-formylaminoantipyrine, 0.7μM for sulpyrine, 1μM for 4-aminoantipyrine, and 2μM for 4-methylaminoantipyrine at the signal-to-noise ratio of 5 : 1.</description><subject>Aminopyrine - analogs & derivatives</subject><subject>Aminopyrine - blood</subject><subject>Analysis</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Dipyrone - blood</subject><subject>General pharmacology</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>plasma concentration</subject><subject>Rabbits</subject><issn>0009-2363</issn><issn>1347-5223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkcuP0zAQxi0EWsrCiTOSJVZcUIofcWIfV-WxlYqoeJytiWO3LkmctZND_3tctRSJi8fS99PMN_Mh9JqSJWWl_GDGZsnZklNVPkELysu6EIzxp2hBCFEF4xV_jl6kdCCECVLzG3RTCSqFkgv0ex2GYgs-4ge_2xdbG12IPQzG4o1_nH2LV_sYepjCLsK49wbfD9Adk084OPxj7sZj9IPFMLR4PSX81U7QhM5PNmE_4O_QNH7C2w5SDy_RMwddsq8u9Rb9-vzp5-qh2Hz7sl7dbwpTcTEVitW0pIQxMIq2rM4_VkvgUjgG2TQFV_HSSdlYLlXT5qLayjlDa2GskPwWvTv3HWN4nG2adO-TsV0Hgw1z0rWQJWWcZPDtf-AhzDHvlzQthVJCVqLM1PszZWJIKVqnx-h7iEdNiT4FoHMAmjN9CiDTby4956a37ZW9XDzrdxcdkoHOxXxrn66YYoTx8mTt4xk7pAl29qpDnLzp7Gkkzf5OY_8-efo_eQ9R24H_AcRhpLk</recordid><startdate>19840101</startdate><enddate>19840101</enddate><creator>ITOH, SOICHI</creator><creator>TANABE, KAZUHISA</creator><creator>FURUICHI, YUMI</creator><creator>SUZUKA, TAKUMI</creator><creator>KUBO, KAZUYOSHI</creator><creator>YAMAZAKI, MASARU</creator><creator>KAMADA, AKIRA</creator><general>The Pharmaceutical Society of Japan</general><general>Maruzen</general><general>Japan Science and Technology Agency</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19840101</creationdate><title>Ion-Pair High-Performance Liquid Chromatographic Analysis of Sulpyrine and Its Metabolites in Rabbit Plasma</title><author>ITOH, SOICHI ; TANABE, KAZUHISA ; FURUICHI, YUMI ; SUZUKA, TAKUMI ; KUBO, KAZUYOSHI ; YAMAZAKI, MASARU ; KAMADA, AKIRA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c635t-927141022ac91d27022278a385f2a5981af634f88be389bdbe39d6ffc175ce583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Aminopyrine - analogs & derivatives</topic><topic>Aminopyrine - blood</topic><topic>Analysis</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Chromatography, High Pressure Liquid - methods</topic><topic>Dipyrone - blood</topic><topic>General pharmacology</topic><topic>Medical sciences</topic><topic>Pharmacology. 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Pharm. Bull.</addtitle><date>1984-01-01</date><risdate>1984</risdate><volume>32</volume><issue>8</issue><spage>3194</spage><epage>3198</epage><pages>3194-3198</pages><issn>0009-2363</issn><eissn>1347-5223</eissn><coden>CPBTAL</coden><abstract>A simple, specific and sensitive ion-pair high-performance liquid chromatographic analysis was developed for aminopyrine, sulpyrine and their metabolites (4-methylaminoantipyrine, 4-aminoantipyrine, 4-acetylaminoantipyrine and 4-formylaminoantipyrine) in rabbit plasma. Following deproteinization with acetonitrile and separation on an octadecylsilane-bonded silica column (250×4mm, JASCO Fine SIL C-18), the eluted components were detected with a multiwavelength ultraviolet monitor at 260nm. The mobile phase consisted of 22% (v/v) acetonitrile and 78% (v/v) of an aqueous solution containing 10mM KH2PO4 and 1.24mM tetra-n-butylammonium bromide, adjusted to pH 4.5 with 0.1M phosphoric acid solution. Hexobarbital was employed as an internal standard. Based on 0.1ml of plasma, the detection limits were 0.35μM for 4-acetylaminoantipyrine, 0.35μM for 4-formylaminoantipyrine, 0.7μM for sulpyrine, 1μM for 4-aminoantipyrine, and 2μM for 4-methylaminoantipyrine at the signal-to-noise ratio of 5 : 1.</abstract><cop>Tokyo</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>6518598</pmid><doi>10.1248/cpb.32.3194</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Chemical and Pharmaceutical Bulletin, 1984/08/25, Vol.32(8), pp.3194-3198 |
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| source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Aminopyrine - analogs & derivatives Aminopyrine - blood Analysis Animals Biological and medical sciences Chromatography, High Pressure Liquid - methods Dipyrone - blood General pharmacology Medical sciences Pharmacology. Drug treatments plasma concentration Rabbits |
| title | Ion-Pair High-Performance Liquid Chromatographic Analysis of Sulpyrine and Its Metabolites in Rabbit Plasma |
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