Peptides and blood-brain barrier transport

Peptides are chemical signals of intercellular communication, and those released into and distributed by the circulatory system can be entrapped by specific binding sites on dozens of cell populations throughout the body. The transfer of peptides through the endothelial cell layer of the brain vascu...

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Veröffentlicht in:	Physiological reviews 1993-07, Vol.73 (3), p.489-527
Hauptverfasser:	ERMISCH, A, BRUST, P, KRETZSCHMAR, R, RÜHLE, H.-J
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animals Biological and medical sciences Biological Transport Blood-Brain Barrier Cellular biology Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges Cerebrovascular Circulation Circulatory system Endothelium, Vascular - cytology Endothelium, Vascular - metabolism Fundamental and applied biological sciences. Psychology Humans Microcirculation Peptides - physiology Receptors, Cell Surface - metabolism Vertebrates: nervous system and sense organs
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Beschreibung
Zusammenfassung:	Peptides are chemical signals of intercellular communication, and those released into and distributed by the circulatory system can be entrapped by specific binding sites on dozens of cell populations throughout the body. The transfer of peptides through the endothelial cell layer of the brain vasculature and the blood-brain barrier transport alterations induced by blood-borne peptidic signals are examined, and the results are discussed.
ISSN:	0031-9333 1522-1210
DOI:	10.1152/physrev.1993.73.3.489