Induction of Apoptosis by the Low-Affinity NGF Receptor

Nerve growth factor (NGF) binding to cellular receptors is required for the survival of some neural cells. In contrast to Trk A, the high-affinity NGF receptor that transduces NGF signals for survival and differentiation, the function of the low-affinity NGF receptor, p75$^{NGFR}$, remains uncertain...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Science (American Association for the Advancement of Science) 1993-07, Vol.261 (5119), p.345-348
Hauptverfasser: Rabizadeh, Shahrooz, Oh, Justin, Zhong, Li-tao, Yang, Jie, Bitler, Catherine M., Butcher, Larry L., Bredesen, Dale E.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Nerve growth factor (NGF) binding to cellular receptors is required for the survival of some neural cells. In contrast to Trk A, the high-affinity NGF receptor that transduces NGF signals for survival and differentiation, the function of the low-affinity NGF receptor, p75$^{NGFR}$, remains uncertain. Expression of p75$^{NGFR}$ induced neural cell death constitutively when p75$^{NGFR}$ was unbound; binding by NGF or monoclonal antibody, however, inhibited cell death induced by p75$^{NGFR}$. Thus, expression of p75$^{NGFR}$ may explain the dependence of some neural cells on NGF for survival. These findings also suggest that p75$^{NGFR}$ has some functional similarities to other members of a superfamily of receptors that include tumor necrosis factor receptors, Fas (Apo-1), and CD40.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.8332899