Induction of Apoptosis by the Low-Affinity NGF Receptor
Nerve growth factor (NGF) binding to cellular receptors is required for the survival of some neural cells. In contrast to Trk A, the high-affinity NGF receptor that transduces NGF signals for survival and differentiation, the function of the low-affinity NGF receptor, p75$^{NGFR}$, remains uncertain...
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Veröffentlicht in: | Science (American Association for the Advancement of Science) 1993-07, Vol.261 (5119), p.345-348 |
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Sprache: | eng |
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Zusammenfassung: | Nerve growth factor (NGF) binding to cellular receptors is required for the survival of some neural cells. In contrast to Trk A, the high-affinity NGF receptor that transduces NGF signals for survival and differentiation, the function of the low-affinity NGF receptor, p75$^{NGFR}$, remains uncertain. Expression of p75$^{NGFR}$ induced neural cell death constitutively when p75$^{NGFR}$ was unbound; binding by NGF or monoclonal antibody, however, inhibited cell death induced by p75$^{NGFR}$. Thus, expression of p75$^{NGFR}$ may explain the dependence of some neural cells on NGF for survival. These findings also suggest that p75$^{NGFR}$ has some functional similarities to other members of a superfamily of receptors that include tumor necrosis factor receptors, Fas (Apo-1), and CD40. |
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ISSN: | 0036-8075 1095-9203 |
DOI: | 10.1126/science.8332899 |