Influenza A/Philippines/2/82 outbreak in a nursing home: Limitations of influenza vaccination in the aged

Influenza A/Philippines/2/82 outbreak in a nursing home: Limitations of influenza vaccination in the aged

The failure of the 1982–1983 influenza vaccine to protect elderly NHCU residents from clinical infection with influenza A/Philippines/2/82 resulted primarily from antigenic drift of the epidemic strain, inasmuch as the attack rates in the vaccinated and nonvaccinated patients were not significantly...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:American journal of infection control 1984-12, Vol.12 (6), p.329-334
Hauptverfasser: Arroyo, Julio C., Postic, B., Brown, Arnold, Harrison, Kathy, Birgenheier, Robert, Dowda, Harold
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Age Factors
Aged
Antibodies, Viral - analysis
Antigens, Viral - immunology
Cross Infection - epidemiology
Disease Outbreaks - prevention & control
Female
Humans
Influenza A virus - immunology
Influenza Vaccines
Influenza, Human - epidemiology
Influenza, Human - immunology
Influenza, Human - prevention & control
Male
Middle Aged
Nursing Homes
Patient Isolation
South Carolina
Vaccination
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Beschreibung
Zusammenfassung:The failure of the 1982–1983 influenza vaccine to protect elderly NHCU residents from clinical infection with influenza A/Philippines/2/82 resulted primarily from antigenic drift of the epidemic strain, inasmuch as the attack rates in the vaccinated and nonvaccinated patients were not significantly different. This experience supports the decision to replace A/Bangkok/1/79 with A/Philippines/2/82 virus antigen in the 1983–1984 influenza vaccine. 10
ISSN:0196-6553
1527-3296
DOI:10.1016/0196-6553(84)90005-1