Ethanol and diazepam inhibition of hippocampal LTP is mediated by angiotensin II and AT1 receptors

Angiotensin II (AII) inhibits the induction of hippocampal long-term potentiation (LTP), a frequency-dependent model of learning and memory. These results demonstrate that the dose-dependent inhibition of LTP due to ethanol (EtOH) and diazepam (DZ) involves AII. Inhibition of LTP induction by AII, E...

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Veröffentlicht in:	Peptides (New York, N.Y. : 1980) N.Y. : 1980), 1993-05, Vol.14 (3), p.441-444
Hauptverfasser:	WAYNER, M. J, ARMSTRONG, D. L, POLAN-CURTAIN, J. L, DENNY, J. B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Cognition - physiology Diazepam - pharmacology Ethanol - pharmacology Fundamental and applied biological sciences. Psychology Hippocampus - drug effects Male Neuronal Plasticity - drug effects Rats Rats, Sprague-Dawley Receptors, Angiotensin - drug effects Receptors, Angiotensin - physiology Vertebrates: nervous system and sense organs
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Zusammenfassung:	Angiotensin II (AII) inhibits the induction of hippocampal long-term potentiation (LTP), a frequency-dependent model of learning and memory. These results demonstrate that the dose-dependent inhibition of LTP due to ethanol (EtOH) and diazepam (DZ) involves AII. Inhibition of LTP induction by AII, EtOH, and DZ can be blocked by AII receptor antagonists saralasin and lorsartan (DuP 753). Lorsartan is a competitive antagonist of the AT1 subtype AII receptor. Therefore, the EtOH and DZ inhibition of LTP induction is mediated by AT1 receptors. These results indicate a new role for AII in the brain in the possible mediation of memory deficits associated with alcohol and the benzodiazepines.
ISSN:	0196-9781 1873-5169
DOI:	10.1016/0196-9781(93)90129-5