Cloning and expression of cDNA for human lymphotoxin, a lymphokine with tumour necrosis activity

A chemically-synthesized gene and natural complementary DNA coding for human lymphotoxin were isolated and engineered for expression in Escherichia coli . Purified recombinant lymphotoxin shows cytotoxic activity on murine and human tumour cell lines in vitro and causes necrosis of certain murine sa...

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Veröffentlicht in:	Nature (London) 1984-01, Vol.312 (5996), p.721-724
Hauptverfasser:	Gray, Patrick W, Aggarwal, Bharat B, Benton, Charles V, Bringman, Timothy S, Henzel, William J, Jarrett, Julie A, Leung, David W, Moffat, Barbara, Ng, Peter, Svedersky, Lloyd P, Palladino, Michael A, Nedwin, Glenn E
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Analysis of the immune response. Humoral and cellular immunity Animals Base Sequence Biological and medical sciences Cell interactions Cells, Cultured Cloning, Molecular DNA - genetics Fundamental and applied biological sciences. Psychology Fundamental immunology Gene Expression Regulation Humanities and Social Sciences Humans Immunobiology Lymphokines - genetics Lymphotoxin-alpha - genetics Lymphotoxin-alpha - therapeutic use Mice multidisciplinary Sarcoma, Experimental - therapy Science Science (multidisciplinary)
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Beschreibung
Zusammenfassung:	A chemically-synthesized gene and natural complementary DNA coding for human lymphotoxin were isolated and engineered for expression in Escherichia coli . Purified recombinant lymphotoxin shows cytotoxic activity on murine and human tumour cell lines in vitro and causes necrosis of certain murine sarcomas in vivo .
ISSN:	0028-0836 1476-4687
DOI:	10.1038/312721a0