Immunization with recombinant woodchuck hepatitis virus nucleocapsid antigen or hepatitis B virus nucleocapsid antigen protects woodchucks from woodchuck hepatitis virus infection

Woodchucks were immunized with recombinant woodchuck hepatitis virus (WHV) nucleocapsid antigen (WHcAg) or hepatitis B virus (HBV) nucleocapsid antigen (HBcAg) and challenged with 10 6 WHV ID 50. Six out of six woodchucks immunized with WHcAg and four out of six immunized with HBcAg were protected f...

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Veröffentlicht in:	Vaccine 1993, Vol.11 (6), p.624-628
Hauptverfasser:	Schödel, Florian, Neckermann, Georg, Peterson, Darrell, Fuchs, Klaus, Fuller, Steve, Will, Hans, Roggendorf, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Viral - biosynthesis Base Sequence Biological and medical sciences Blotting, Western Capsid - immunology Cross Reactions Electrophoresis, Polyacrylamide Gel Fundamental and applied biological sciences. Psychology Hepadnaviridae - immunology Hepatitis B Antibodies - biosynthesis Hepatitis B Core Antigens - immunology Hepatitis B virus Hepatitis, Viral, Animal - immunology Hepatitis, Viral, Animal - prevention & control Marmota Marmota monax Microbiology Molecular Sequence Data protection recombinant T cells Vaccination Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Vaccines, Synthetic - immunology Viral Core Proteins - immunology Viral Hepatitis Vaccines - immunology Virology woodchuck hepatitis virus
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Zusammenfassung:	Woodchucks were immunized with recombinant woodchuck hepatitis virus (WHV) nucleocapsid antigen (WHcAg) or hepatitis B virus (HBV) nucleocapsid antigen (HBcAg) and challenged with 10 6 WHV ID 50. Six out of six woodchucks immunized with WHcAg and four out of six immunized with HBcAg were protected from WHV infection. Woodchucks immunized with WHcAg or HBcAg developed high serum antibody titres against WHcAg or HBcAg. Antibodies against WHc and HBc displayed little cross-reactivity (
ISSN:	0264-410X 1873-2518
DOI:	10.1016/0264-410X(93)90307-J