PHENACEIN-AN ANGIOTENSIN-CONVERTING ENZYME INHIBITOR PRODUCED BY A STREPTOMYCETE: II. ISOLATION, STRUCTURE DETERMINATION AND SYNTHESIS

PHENACEIN-AN ANGIOTENSIN-CONVERTING ENZYME INHIBITOR PRODUCED BY A STREPTOMYCETE: II. ISOLATION, STRUCTURE DETERMINATION AND SYNTHESIS

Phenacein, an inhibitor of angiotensin-converting enzyme, has been isolated from the fermentation broth of a Streptomyces species belonging to the Streptomyces tanashiensiszaomyceticus group. The inhibitor was shown to be 3, 6-dihydroxy-1-phenazinecarboxylic acid by spectroscopic, degradative and sy...

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Veröffentlicht in:Journal of antibiotics 1984, Vol.37(11), pp.1313-1319
Hauptverfasser: LIU, WEN-CHIH, PARKER, WILLIAM L., BRANDT, STEVEN S., ATWAL, KARNAIL S., RUBY, ERIC P.
Format: Artikel
Sprache:eng
Schlagworte:
Angiotensin-Converting Enzyme Inhibitors
Biological and medical sciences
Biotechnology
Chemical Phenomena
Chemistry
Fundamental and applied biological sciences. Psychology
General pharmacology
Health. Pharmaceutical industry
Industrial applications and implications. Economical aspects
Medical sciences
Other active biomolecules
Pharmacology. Drug treatments
Phenazines - chemical synthesis
Phenazines - isolation & purification
Physicochemical properties. Structure-activity relationships
Production of active biomolecules
Streptomyces
Streptomyces - metabolism
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Zusammenfassung:Phenacein, an inhibitor of angiotensin-converting enzyme, has been isolated from the fermentation broth of a Streptomyces species belonging to the Streptomyces tanashiensiszaomyceticus group. The inhibitor was shown to be 3, 6-dihydroxy-1-phenazinecarboxylic acid by spectroscopic, degradative and synthetic methods.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.37.1313