Non- linear accumulation of gentamicin in guinea-pig kidney
The dose dependence of gentamicin renal uptake in guinea-pigs was studied. The concentration of gentamicin in the kidneys was determined 2 h post administration. The plot of gentamicin concentration vs. dose over the range 0.3–48 mg/kg iv revealed nonlinearity of the uptake. As the delivery of genta...
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| Veröffentlicht in: | Journal of antimicrobial chemotherapy 1984-11, Vol.14 (5), p.543-548 |
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| container_end_page | 548 |
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| container_issue | 5 |
| container_start_page | 543 |
| container_title | Journal of antimicrobial chemotherapy |
| container_volume | 14 |
| creator | Trnovec, T. Bezek, Š. Kállay, Z. Ďurišová, M. Navarová, J. |
| description | The dose dependence of gentamicin renal uptake in guinea-pigs was studied. The concentration of gentamicin in the kidneys was determined 2 h post administration. The plot of gentamicin concentration vs. dose over the range 0.3–48 mg/kg iv revealed nonlinearity of the uptake. As the delivery of gentamicin to proximal tubule cells apparently obeys first order kinetics, the nonlinear process should occur at the cellular uptake level. |
| doi_str_mv | 10.1093/jac/14.5.543 |
| format | Article |
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The concentration of gentamicin in the kidneys was determined 2 h post administration. The plot of gentamicin concentration vs. dose over the range 0.3–48 mg/kg iv revealed nonlinearity of the uptake. As the delivery of gentamicin to proximal tubule cells apparently obeys first order kinetics, the nonlinear process should occur at the cellular uptake level.</description><identifier>ISSN: 0305-7453</identifier><identifier>EISSN: 1460-2091</identifier><identifier>DOI: 10.1093/jac/14.5.543</identifier><identifier>PMID: 6511708</identifier><identifier>CODEN: JACHDX</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Animals ; Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Biological and medical sciences ; Dose-Response Relationship, Drug ; Gentamicins - blood ; Gentamicins - metabolism ; Guinea Pigs ; Injections, Intravenous ; Kidney - metabolism ; Kinetics ; Male ; Medical sciences ; Pharmacology. 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The concentration of gentamicin in the kidneys was determined 2 h post administration. The plot of gentamicin concentration vs. dose over the range 0.3–48 mg/kg iv revealed nonlinearity of the uptake. As the delivery of gentamicin to proximal tubule cells apparently obeys first order kinetics, the nonlinear process should occur at the cellular uptake level.</description><subject>Animals</subject><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Biological and medical sciences</subject><subject>Dose-Response Relationship, Drug</subject><subject>Gentamicins - blood</subject><subject>Gentamicins - metabolism</subject><subject>Guinea Pigs</subject><subject>Injections, Intravenous</subject><subject>Kidney - metabolism</subject><subject>Kinetics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><issn>0305-7453</issn><issn>1460-2091</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo90M9LwzAUB_AgypzTm1ehB_Fkt6TJS1s86fwxYUxBBfES0jQd2dp0Ni24_96MlcGDd_h-ePC-CF0SPCY4pZOVVBPCxjAGRo_QkDCOwwin5BgNMcUQxgzoKTpzboUx5sCTARpwICTGyRDdLWobBqWxWjaBVKqrulK2prZBXQRLbVtZGWVs4GfZ7VS4MctgbXKrt-fopJCl0xf9HqGv56fP6Sycv728Tu_noaJA2zArmCaM5almkkDKecTjNCpUnjDINCgmU0wyiKFgEBOW5xloSnhO_Q-apZKO0M3-7qapfzvtWlEZp3RZSqvrzokYkgiziHt4u4eqqZ1rdCE2jalksxUEi11XwnclCBMgfFeeX_V3u6zS-QH35fj8us-lU7IsGmmVcQeWRgAJRJ6Fe2Zcq_8OsWzWgsc0BjH7_hGzx4dFxD7eBaX_qK5_HQ</recordid><startdate>198411</startdate><enddate>198411</enddate><creator>Trnovec, T.</creator><creator>Bezek, Š.</creator><creator>Kállay, Z.</creator><creator>Ďurišová, M.</creator><creator>Navarová, J.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198411</creationdate><title>Non- linear accumulation of gentamicin in guinea-pig kidney</title><author>Trnovec, T. ; Bezek, Š. ; Kállay, Z. ; Ďurišová, M. ; Navarová, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-bf4e144d9e4a1596626792fcd845be5c4a901b575f45714ddb5e316d3091e49a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Animals</topic><topic>Antibacterial agents</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Biological and medical sciences</topic><topic>Dose-Response Relationship, Drug</topic><topic>Gentamicins - blood</topic><topic>Gentamicins - metabolism</topic><topic>Guinea Pigs</topic><topic>Injections, Intravenous</topic><topic>Kidney - metabolism</topic><topic>Kinetics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacology. 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The concentration of gentamicin in the kidneys was determined 2 h post administration. The plot of gentamicin concentration vs. dose over the range 0.3–48 mg/kg iv revealed nonlinearity of the uptake. As the delivery of gentamicin to proximal tubule cells apparently obeys first order kinetics, the nonlinear process should occur at the cellular uptake level.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>6511708</pmid><doi>10.1093/jac/14.5.543</doi><tpages>6</tpages></addata></record> |
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| ispartof | Journal of antimicrobial chemotherapy, 1984-11, Vol.14 (5), p.543-548 |
| issn | 0305-7453 1460-2091 |
| language | eng |
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| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy |
| subjects | Animals Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Dose-Response Relationship, Drug Gentamicins - blood Gentamicins - metabolism Guinea Pigs Injections, Intravenous Kidney - metabolism Kinetics Male Medical sciences Pharmacology. Drug treatments |
| title | Non- linear accumulation of gentamicin in guinea-pig kidney |
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