Non- linear accumulation of gentamicin in guinea-pig kidney

The dose dependence of gentamicin renal uptake in guinea-pigs was studied. The concentration of gentamicin in the kidneys was determined 2 h post administration. The plot of gentamicin concentration vs. dose over the range 0.3–48 mg/kg iv revealed nonlinearity of the uptake. As the delivery of genta...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 1984-11, Vol.14 (5), p.543-548
Hauptverfasser:	Trnovec, T., Bezek, Š., Kállay, Z., Ďurišová, M., Navarová, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Dose-Response Relationship, Drug Gentamicins - blood Gentamicins - metabolism Guinea Pigs Injections, Intravenous Kidney - metabolism Kinetics Male Medical sciences Pharmacology. Drug treatments
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Zusammenfassung:	The dose dependence of gentamicin renal uptake in guinea-pigs was studied. The concentration of gentamicin in the kidneys was determined 2 h post administration. The plot of gentamicin concentration vs. dose over the range 0.3–48 mg/kg iv revealed nonlinearity of the uptake. As the delivery of gentamicin to proximal tubule cells apparently obeys first order kinetics, the nonlinear process should occur at the cellular uptake level.
ISSN:	0305-7453 1460-2091
DOI:	10.1093/jac/14.5.543