THE STRUCTURE AND ABSOLUTE STEREOCHEMISTRY OF ZINCOPHORIN (ANTIBIOTIC M144255): A MONOBASIC CARBOXYLIC ACID IONOPHORE HAVING A REMARKABLE SPECIFICITY FOR DIVALENT CATIONS

In the course of our search for natural ionophores with ruminant growth promoting properties, the authors have previously reported the structure of antibiotic M139603, the first tetronic acid-containing polyether. The authors now wish to describe antibiotic M144255, a monocarboxylic acid type ionoph...

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Veröffentlicht in:	Journal of antibiotics 1984, Vol.37(11), pp.1501-1504
Hauptverfasser:	BROOKS, HEATHER A., GARDNER, DONALD, POYSER, J. PHILIP, KING, TREVOR J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - pharmacology Biological and medical sciences Carboxylic Acids General pharmacology Ionophores - pharmacology Magnesium Medical sciences Mice Molecular Conformation Pharmacology. Drug treatments Physicochemical properties. Structure-activity relationships Propionates Rats Streptomyces griseus X-Ray Diffraction Zinc
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Beschreibung
Zusammenfassung:	In the course of our search for natural ionophores with ruminant growth promoting properties, the authors have previously reported the structure of antibiotic M139603, the first tetronic acid-containing polyether. The authors now wish to describe antibiotic M144255, a monocarboxylic acid type ionophore from a strain of Streptomyces griseus . It has a high affinity for divalent cations especially zinc, for which reason it was given the trivial name, zincophorin. The molecular structure and absolute stereochemistry were determined by X-ray analysis on the mixed zinc-magnesium salt.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.37.1501