The effects of phenobarbital, bis- p-nitrophenyl phosphate and disulfiram on the hydrolysis of propanidid in Wistar rats

1. 1. The short-acting anesthetic propanidid was used in vivo as a model substrate in studies of phenobarbital-inducible carboxylesterases in Wistar rats. 2. 2. Phenobarbital shortened the duration of anesthesia produced by intravenous (25 mg/kg) or intraperitoneal (750 mg/kg) administration of propanidid which was in good agreement with the lowered plasma concentration and the shortened half-life of propanidid in phenobarbital-pretreated rats. 3. 3. The treatment of rats with bis- p-nitrophenyl phosphate or disulfiram with or without phenobarbital-pretreatment prolonged the sleeping time and the half-life of propanidid in plasma.