ISOLATION AND CHARACTERIZATION OF CONCANAMYCINS A, B AND C

Concanamycins A, B and C were isolated from the mycelium of Streptomyces diastatochromogenes S-45 as effective inhibitors of the proliferation of mouse splenic lymphocytes stimulated by concanavalin A. They represent a new class of 18-membered macrolide antibiotics, and are biologically active in vi...

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Veröffentlicht in:	Journal of antibiotics 1984, Vol.37(11), pp.1333-1343
Hauptverfasser:	KINASHI, HARUYASU, SOMENO, KINUMI, SAKAGUCHI, KENJI
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Antibiotics Biological and medical sciences Biotechnology Chemical Phenomena Chemistry Fermentation Fundamental and applied biological sciences. Psychology General pharmacology Health. Pharmaceutical industry Industrial applications and implications. Economical aspects Lactones - isolation & purification Lymphocyte Activation - drug effects Macrolides Medical sciences Mice Microbial Sensitivity Tests Pharmacology. Drug treatments Physicochemical properties. Structure-activity relationships Production of active biomolecules Streptomyces - metabolism
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Beschreibung
Zusammenfassung:	Concanamycins A, B and C were isolated from the mycelium of Streptomyces diastatochromogenes S-45 as effective inhibitors of the proliferation of mouse splenic lymphocytes stimulated by concanavalin A. They represent a new class of 18-membered macrolide antibiotics, and are biologically active in vitro against several fungi and yeasts, but not against bacteria. Concanamycin A, the main component, has been identified with antifungal antibiotics, folimycin and A-661-I.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.37.1333